FOGSAA – Fast Optimal Global Sequence Alignment

FOGSAA

:: DESCRIPTION

FOGSAA aligns a pair of nucleotide/protein sequences faster than any optimal global alignment method including the widely used Needleman-Wunsch (NW) algorithm.

::DEVELOPER

Bioinformatics Lab (MIU)

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 FOGSAA

:: MORE INFORMATION

Citation

Sci Rep. 2013;3:1746. doi: 10.1038/srep01746.
FOGSAA: Fast Optimal Global Sequence Alignment Algorithm.
Chakraborty A1, Bandyopadhyay S.

FALP 1.06 – Calculation of the Gumbel Parameters for Frameshift Sequence Alignment

FALP 1.06

:: DESCRIPTION

FALP calculates the statistical parameters in the modified Gumbel distribution for gapped alignment with frameshifts.

::DEVELOPER

Spouge Research Group

:: SCREENSHOTS

Command Line

:: REQUIREMENTS

  • Linux / Windows

:: DOWNLOAD

 FALP

:: MORE INFORMATION

Citation

ALP & FALP: C++ Libraries for pairwise local alignment E-values.
Sheetlin S, Park Y, Frith MC, Spouge JL.
Bioinformatics. 2015 Oct 1. pii: btv575.

Frameshift alignment: statistics and post-genomic applications.
Sheetlin SL, Park Y, Frith MC, Spouge JL.
Bioinformatics. 2014 Aug 28. pii: btu576.

oculus 0.1.2 – Faster Sequence Alignment by Compression

oculus 0.1.2

:: DESCRIPTION

Oculus is a bioinformatic algorithm designed to increase sequence alignment speed for redundant input. It acts as a wrapper around any existing alignment algorithm capable of producing SAM-formatted output.

::DEVELOPER

The Michigan Center for Translational Pathology

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • Perl

:: DOWNLOAD

Oculus

:: MORE INFORMATION

BMC Bioinformatics. 2012 Nov 13;13:297. doi: 10.1186/1471-2105-13-297.
Oculus: faster sequence alignment by streaming read compression.
Veeneman BA1, Iyer MK, Chinnaiyan AM.

GPU-BLAST 1.1 – Sequence Alignment with GPUs

GPU-BLAST 1.1

:: DESCRIPTION

GPU-BLAST is an accelerated version of the popular NCBI-BLAST using a general-purpose graphics processing unit (GPU). The implementation is based on the source code of NCBI-BLAST, thus maintaining the same input and output interface while producing identical results. In comparison to the sequential NCBI-BLAST, the speedups achieved by GPU-BLAST range mostly between 3 and 4.

::DEVELOPER

Sahinidis Group

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • C++
  • CUDA

:: DOWNLOAD

GPU-BLAST

:: MORE INFORMATION

Citation

Panagiotis D. Vouzis and Nikolaos V. Sahinidis,
GPU-BLAST: using graphics processors to accelerate protein sequence alignment,”
Bioinformatics, 2011 Vol. 27, no. 2, pages 182-188,

Ribostral 20070223 – RNA Sequence Alignment Analysis program

Ribostral 20070223

:: DESCRIPTION

Ribostral (Ribonucleic Structural Aligner) is a user-friendly framework for analyzing, evaluating and viewing RNA sequence alignments with at least one available atomic resolution structure. It is the first of its kind that makes direct and easy- to-understand superposition of the isostericity matrices of basepairs observed in the structure onto sequence alignments, easily indicating allowed and unallowed substitutions at each BP position.

::DEVELOPER

BGSU RNA Bioinformatics Lab

:: SCREENSHOTS

Ribostral

:: REQUIREMENTS

  • Windows/ Linux / Mac OsX
  • MATLAB

:: DOWNLOAD

 Ribostral

:: MORE INFORMATION

Citation:

Bioinformatics. 2006 Sep 1;22(17):2168-70. Epub 2006 Jul 4.
Ribostral: an RNA 3D alignment analyzer and viewer based on basepair isostericities.
Mokdad A, Leontis NB.

SMRT Analysis 2.3.0 – Software Suite for Sequence Alignment, Assembly, Variant Detection, and Base Modification discovery

SMRT Analysis 2.3.0

:: DESCRIPTION

SMRT Analysis is a bioinformatics software suite for analyzing single molecule, real-time DNA sequencing data from Pacific Biosciences.

::DEVELOPER

Pacific Biosciences of California, Inc

:: SCREENSHOTS

SMRTAnalysis

:: REQUIREMENTS

  • Linux
  • perl
  • Java 

:: DOWNLOAD 

 SMRT Analysis

:: MORE INFORMATION

Citation

Genome Integr. 2011 Dec 20;2:10. doi: 10.1186/2041-9414-2-10.
Direct detection and sequencing of damaged DNA bases.
Clark TA, Spittle KE, Turner SW, Korlach J.

elPrep 5.0.2 – High-Performance Preparation of Sequence Alignment/Map Files for Variant Calling

elPrep 5.0.2

:: DESCRIPTION

elPrep is a high-performance tool for preparing .sam/.bam/.cram files for variant calling in sequencing pipelines.It can be used as a drop-in replacement for SAMtools/Picard, and was extensively tested with different pipelines for variant analysis with GATK.

::DEVELOPER

The Exascience Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • Python

:: DOWNLOAD

 elPrep

:: MORE INFORMATION

Citation

PLoS One. 2015 Jul 16;10(7):e0132868. doi: 10.1371/journal.pone.0132868. eCollection 2015.
elPrep: High-Performance Preparation of Sequence Alignment/Map Files for Variant Calling.
Herzeel C, Costanza P, Decap D, Fostier J, Reumers J

SAT 1.2 – Sequence Alignment Teacher

SAT 1.2

:: DESCRIPTION

SAT is a software to teach about sequence alignment methods based on dynamic programming such as Smith – Waterman (Local) and Needleman – Wunsch (Global).

::DEVELOPER

Francisco Melo Ledermann

:: SCREENSHOTS

sat

:: REQUIREMENTS

  • Linux/ Windows/ MacOsX
  • Java

:: DOWNLOAD

 SAT

:: MORE INFORMATION

Citation

Bioinformatics. 2010 Jul 1;26(13):1664-5. doi: 10.1093/bioinformatics/btq252. Epub 2010 May 14.
Interactive software tool to comprehend the calculation of optimal sequence alignments with dynamic programming.
Ibarra IL1, Melo F.

PhySamp 1.1.0 – Phylogenetic Sampling and Optimization of Sequence Alignments

PhySamp 1.1.0

:: DESCRIPTION

PhySamp is a package dedicated to phylogenetic sampling. It samples a sequence alignment according to its corresponding phylogenetic tree.

::DEVELOPER

Dr Julien Y. Dutheil

:: SCREENSHOTS

N/A

:: REQUIREMENTS

:: DOWNLOAD

PhySamp

:: MORE INFORMATION

Citation

Dutheil JY1,2, Figuet E3.
Optimization of sequence alignments according to the number of sequences vs. number of sites trade-off.
BMC Bioinformatics. 2015 Jun 9;16:190.

ICM-Browser 3.9-2b – Molecules & Sequence Alignments Visualization

ICM-Browser 3.9-2b

:: DESCRIPTION

ICM-Browser provides a biologist or a chemist with direct access to the treasures of structural biology and protein families.It reads a variety of file formats directly from the database web-sites including: PDB, chemical, electron density maps, sequence and alignment files. ICM-Browser provides a rich professional molecular graphics environment with powerful representations of proteins, DNA and RNA, and multiple sequence alignments.

When you purchase the license ICM-Browser will become ICM-Browser-Pro.ICM-Browser-Pro is a high quality visualizer and annotator for three dimensional molecular structures, sequences, alignments, chemical spreadsheets and biological data. It allows you to read data from multiple file formats, annotate the data, and write multi-slide documents in a single small cross-platform file. ICM Browser Pro is well suited for creating, storing and sharing structural, biological and chemical information. The files can then be opened and viewed with the free ICM Browser.

::DEVELOPER

Molsoft LLC.

:: SCREENSHOTS

:: REQUIREMENTS

  • Windows/Linux/Mac OS X

:: DOWNLOAD

ICM-Browser ; Manual

:: MORE INFORMATION