DRBTool – Determine HLA Genotypes at the DRB1 locus

DRBTool

:: DESCRIPTION

DRBTool supports a new technique for determining HLA genotypes at the DRB1 locus through non-electrophoretic scoring of group-specific PCR.

::DEVELOPER

Institute for Clinical Molecular Biology

:: SCREENSHOTS

N/A

::REQUIREMENTS

  • Windows
  • MS SQL

:: DOWNLOAD

 DRBTool

:: MORE INFORMATION

Citation

Hampe J, Valentonyte R, Manaster C, Teuber M, Jenisch S, Entz P, Nagy M, Schreiber S (2004).
Nonelectrophoretic method for high-throughput HLA-DRB1 group genotyping.
BioTechniques 36: 148-151

HIBAG 1.28.0 – HLA Genotype Imputation with Attribute Bagging

HIBAG 1.28.0

:: DESCRIPTION

HIBAG is a state of the art software package for imputing HLA types using SNP data, and it uses the R statistical programming language. HIBAG is highly accurate, computationally tractable, and can be used by researchers with published parameter estimates (provided for subjects of European, Asian, Hispanic and African ancestries) instead of requiring access to large training sample datasets. It combines the concepts of attribute bagging, an ensemble classifier method, with haplotype inference for SNPs and HLA types. Attribute bagging is a technique which improves the accuracy and stability of classifier ensembles deduced using bootstrap aggregating and random subsets of variables.

::DEVELOPER

HIBAG team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows / MacOsX / Linux
  • R
  • BioConductor

:: DOWNLOAD

 HIBAG

:: MORE INFORMATION

Citation

X. Zheng, J. Shen, C. Cox, J. Wakefield, M. Ehm, M. Nelson, B. Weir.
HIBAG – HLA Genotype Imputation with Attribute Bagging
Pharmacogenomics J. 2013 May 28. doi: 10.1038/tpj.2013.18.

HLAminer 1.4 – Derivation of HLA class I Predictions from Shotgun sequence datasets

HLAminer 1.4

:: DESCRIPTION

HLAminer is a software for HLA class I predictions from next-generation shotgun (NGS) sequence read data that supports direct read alignment (HPRA) and targeted assembly of sequence reads (HPTASR).

::DEVELOPER

Canada’s Michael Smith Genome Sciences Centre

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 HLAminer

:: MORE INFORMATION

Citation

Genome Med. 2012 Dec 10;4(12):95.
Derivation of HLA types from shotgun sequence datasets.
Warren RL, Choe G, Freeman DJ, Castellarin M, Munro S, Moore R, Holt RA.

HLA-IMPUTER – HLA Imputation and Association analysis using Population-specific Reference Panels

HLA-IMPUTER

:: DESCRIPTION

HLA-IMPUTER implements the HIBAG algorithm for HLA allele imputation with different population specific reference panels, including a new Han Chinese reference panel derived from 10,689 samples.

::DEVELOPER

WANLING YANG’S GROUP IN BIOINFORMATICS @ University of Hong Kong

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web browser

:: DOWNLOAD

  NO

:: MORE INFORMATION

Citation

Bioinformatics. 2019 Apr 1;35(7):1244-1246. doi: 10.1093/bioinformatics/bty730.
HLA-IMPUTER: an easy to use web application for HLA imputation and association analysis using population-specific reference panels.
Shen JJ, Yang C, Wang YF, Wang TY, Guo M, Lau YL, Zhang X, Sheng Y, Yang W.

DHLAS – Web-based Information System for Statistical Genetic Analysis of HLA Population data

DHLAS

:: DESCRIPTION

DHLAS (database HLA system) is a user-friendly, web-based information system for the analysis of human leukocyte antigens (HLA) data from population studies.

::DEVELOPER

Department of Biomathematics. School of Medicine. University of Thessaly.

:: SCREENSHOTS

N/A

:: REQUIREMENTS

:: DOWNLOAD

 DHLAS

:: MORE INFORMATION

Citation

Thriskos P, Zintzaras E, Germenis A.
DHLAS: A web-based information system for statistical genetic analysis of HLA population data.
Comput Methods Programs Biomed. 2007 Mar;85(3):267-72. Epub 2006 Dec 28.