CREEDS – Crowd Extracted Expression of Differential Signatures

CREEDS

:: DESCRIPTION

CREEDS is a portal for visualizing and querying the collections of the gene expression signatures.

::DEVELOPER

Ma’ayan Laboratory

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web browser

:: DOWNLOAD

NO

:: MORE INFORMATION

Citation

Nat Commun. 2016 Sep 26;7:12846. doi: 10.1038/ncomms12846.
Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd.
Wang Z etc.

ARCHS4 – All RNA-seq and CHIP-seq Signature Search Space

ARCHS4

:: DESCRIPTION

ARCHS4 is a web resource that makes the majority of published RNA-seq data from human and mouse available at the gene and transcript levels.

::DEVELOPER

Ma’ayan Laboratory

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web browser

:: DOWNLOAD

ARCHS4

:: MORE INFORMATION

Citation

Nat Commun. 2018 Apr 10;9(1):1366. doi: 10.1038/s41467-018-03751-6.
Massive mining of publicly available RNA-seq data from human and mouse.
Lachmann A, Torre D, Keenan AB, Jagodnik KM, Lee HJ, Wang L, Silverstein MC, Ma’ayan A.

Genefu 2.23.1 – Computation of Gene Expression-Based Signatures in Breast Cancer

Genefu 2.23.1

:: DESCRIPTION

Genefu contains functions implementing various tasks usually required by gene expression analysis, especially in breast cancer studies: gene mapping between different microarray platforms, identification of molecular subtypes, implementation of published gene signatures, gene selection, and survival analysis.

::DEVELOPER

Princess Margaret Bioinformatics and Computational Genomics Laboratory

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows/Linux/MacOsX
  • R/Bioconductor

:: DOWNLOAD

 Genefu

:: MORE INFORMATION

Citation:

Genefu: an R/Bioconductor package for computation of gene expression-based signatures in breast cancer.
Gendoo DM, Ratanasirigulchai N, Schröder MS, Paré L, Parker JS, Prat A, Haibe-Kains B.
Bioinformatics. 2015 Nov 24. pii: btv693.

SCUDO – Signature-based Clustering of Expression Profiles

SCUDO

:: DESCRIPTION

SCUDO (Signature-based ClUstering for DiagnOstic purposes) is a tool for clustering gene expression profiles for diagnostic purposes using a new type of rank-based signatures

::DEVELOPER

The Microsoft Research – University of Trento Centre for Computational and Systems Biology

:: SCREENSHOTS

N/a

:: REQUIREMENTS

  • Web browser

:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation

SCUDO: a tool for signature-based clustering of expression profiles.
Lauria M, Moyseos P, Priami C.
Nucleic Acids Res. 2015 May 9. pii: gkv449.

MetaProb v2 – Accurate Metagenomic Reads Binning based on Probabilistic Sequence Signatures

MetaProb v2

:: DESCRIPTION

MetaProb is a novel assembly-assisted tool for unsupervised metagenomic binning.

::DEVELOPER

Matteo Comin

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

MetaProb 

:: MORE INFORMATION

Citation

Bioinformatics, 32 (17), i567-i575 2016 Sep 1
MetaProb: Accurate Metagenomic Reads Binning Based on Probabilistic Sequence Signatures
Samuele Girotto 1, Cinzia Pizzi 1, Matteo Comin 1

MARQ – Mine GEO for Experiments with Similar or opposite Gene Expression Signatures

MARQ

:: DESCRIPTION

MARQ (Microarray Rank Query) is an online microarray retrieval tool based on rank statistics. Datasets in MARQ, most of them retrieved from GEO, are processed into signatures, which are lists of genes ranked by their level of differential expression. Each dataset defines one of more of these signatures based on the possible comparisons of its constituent samples.

::DEVELOPER

MARQ team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  •  Web Browser

:: DOWNLOAD

 No

:: MORE INFORMATION

Citation

Vazquez, M., Nogales-Cadenas, R., Arroyo, J., Botías, P., García, R., Carazo, J. M., Tirado, F., Pascual-Montano, A. Carmona-Saez, P. 2010,
`MARQ: an online tool to mine GEO for experiments with similar or opposite gene expression signatures.’ ,
Nucleic Acids Res. 2010 Jul;38(Web Server issue):W228-32.

ChAT – Unsupervised algorithm to Search Combinatorial Chromatin Signatures.

ChAT

:: DESCRIPTION

ChAT (Chromatin-profile Alignment followed by Tree-clustering algorithm) employs dynamic programming of combinatorial histone modification profiles to identify locally similar chromatin sub-regions and provides complementary utility with respect to existing methods.

::DEVELOPER

Jordan Lab

:: SCREENSHOTS

N/A

::REQUIREMENTS

  • Linux
  • R Program

:: DOWNLOAD

  ChAT

:: MORE INFORMATION

Citation

Nucleic Acids Res. 2012 Nov;40(21):10642-56. doi: 10.1093/nar/gks848. Epub 2012 Sep 18.
Chromatin signature discovery via histone modification profile alignments.
Wang J, Lunyak VV, Jordan IK.

ChromaSig – Find Common Chromatin Signatures

ChromaSig

:: DESCRIPTION

ChromaSig is an unsupervised learning method, which finds, in an unbiased fashion, commonly occurring chromatin signatures in both tiling microarray and sequencing data.

::DEVELOPER

Ren Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 ChromaSig

:: MORE INFORMATION

Citation

Gary Hon, Bing Ren, Wei Wang
ChromaSig: A Probabilistic Approach to Finding Common Chromatin Signatures in the Human Genome
PLoS Comput Biol 4(10): e1000201.