ChIPOTle 2.0 – Tool For The Analysis Of ChIP-chip Data

ChIPOTle 2.0

:: DESCRIPTION

ChIPOTle (Chromatin ImmunoPrecipitation On Tiled arrays) is a Microsoft Excel add-in Macro that analyzes yeast ChIP-chip data generated on whole-genome tiled arrays.

::DEVELOPER

Buck Lab

:: SCREENSHOTS

ChIPOTle

:: REQUIREMENTS

  • Windows
  • Excel / Perl

:: DOWNLOAD

 ChIPOTle

:: MORE INFORMATION

Citation

Genome Biol. 2005;6(11):R97.
ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data.
Buck MJ, Nobel AB, Lieb JD.

ReMoDiscovery – Inferring Transcriptional Module networks from ChIP-chip-, motif- and microarray data

ReMoDiscovery

:: DESCRIPTION

ReMoDiscovery is an intuitive algorithm to correlate regulatory programs with regulators and corresponding motifs to a set of co-expressed genes. It exploits in a concurrent way three independent data sources: ChIP-chip data, motif information and gene expression profiles.

::DEVELOPER

Kathleen Marchal 

:: SCREENSHOTS

:: REQUIREMENTS

  • Linux /  Windows / MacOsX
  • Java
:: DOWNLOAD

 ReMoDiscovery

:: MORE INFORMATION

Citation

Genome Biol. 2006;7(5):R37. Epub 2006 May 5.
Inferring transcriptional modules from ChIP-chip, motif and microarray data.
Lemmens K, Dhollander T, De Bie T, Monsieurs P, Engelen K, Smets B, Winderickx J, De Moor B, Marchal K.

MAT build 3 – Model-based Analysis of Tiling-arrays for ChIP-chip

MAT build 3

:: DESCRIPTION

MAT (Model-based Analysis of Tiling-array) detect regions enriched by transcription factor chromatin immunoprecipitation (ChIP) on Affymetrix tiling arrays (ChIP-chip). MAT models the baseline probe behavior by considering probe sequence and copy number on each array. It standardizes the probe value through the probe model, eliminating the need for sample normalization. MAT uses an innovative function to score regions for ChIP enrichment, which allows robust P value and false discovery rate calculations. MAT can detect ChIP regions from a single ChIP sample, multiple ChIP samples, or multiple ChIP samples with controls with increasing accuracy. The single-array ChIP region detection feature minimizes the time and monetary costs for laboratories newly adopting ChIP-chip to test their protocols and antibodies and allows established ChIP-chip laboratories to identify samples with questionable quality that might contaminate their data.

::DEVELOPER

X. Shirley Liu Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

:: DOWNLOAD

 MAT

:: MORE INFORMATION

Citation:

Johnson WE, Li W, Meyer CA, Gottardo R, Carroll JS, Brown M and Liu XS:
Model-based analysis of tiling-arrays for ChIP-chip.
Proc. Natl. Acad. Sci. USA 103 (2006) 12457-12462.

ChIPmeta 091009 – HHMM Analysis of ChIP-seq and ChIP-chip Data

ChIPmeta 091009

:: DESCRIPTION

ChIPmeta is a software for the joint analysis of ChIP-seq and ChIP-chip data. Individual channel-level analysis and joint analysis are performed using hidden Markov models.

::DEVELOPER

Hyungwon Choi

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux / MacOsX
  • C Compiler

:: DOWNLOAD

  ChIPmeta

:: MORE INFORMATION

Citation:

H. Choi, A.I. Nesvizhskii, D. Ghosh, and Z.S. Qin (2009),
Hierarchical HMM with Application to Joint Analysis of ChIP-seq and ChIP-chip Data.
Bioinformatics, 25, 1715-21.

TiMAT 3.4.4 – Process Chip-chip Tiling Array Experiments

TiMAT 3.4.4

:: DESCRIPTION

TiMAT is an open-source, Java based set of scripts used for processing chip-chip tiling array experiments. Its four main functionalities are (1) smooth noisy signals, (2) optionally calculate false discovery rates, (3) identify enriched intervals and (4) identify peaks within these enriched intervals. While parts of TiMAT might be used in analyzing expression arrays, other parts, such as the symmetric null-p calculations are not appropriate for such experiments– TiMAT is designed for chip-chip experiments.

::DEVELOPER

the Berkeley Drosophila Transcription Network Project,

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows / Linux / Mac OsX
  • Java

:: DOWNLOAD

 TiMAT

:: MORE INFORMATION