TFBIND – Searching Transcription Factor Binding Sites

TFBIND

:: DESCRIPTION

TFBIND is a software for searching transcription factor binding sites (including TATA boxes, GC boxes, CCAAT boxes, transcription start sites (TSS)).

::DEVELOPER

Laboratory for Medical Science Mathematics

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web browser

:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation

Bioinformatics. 1999 Jul-Aug;15(7-8):622-30.
Estimating transcription factor bindability on DNA.
Tsunoda T, Takagi T.

NAGbinder – Web Server for Predicting N-Acetylglucosamine Binding Sites

NAGbinder

:: DESCRIPTION

NAGbinder is a web server developed for predicting NAG interacting residues in a protein from its primary sequence. This server has following two modules; Sequence based module;PSSM based Module;

::DEVELOPER

NAGbinder team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web Browser

:: DOWNLOAD

  NO

:: MORE INFORMATION

Citation

NAGbinder: An approach for identifying N-acetylglucosamine interacting residues of a protein from its primary sequence.
Patiyal S, Agrawal P, Kumar V, Dhall A, Kumar R, Mishra G, Raghava GPS.
Protein Sci. 2019 Oct 25. doi: 10.1002/pro.3761

LPIcom – Analysis, Comparison and Prediction of Protein Ligand Binding Sites

LPIcom

:: DESCRIPTION

LPIcom is a web server developed for understanding protein-ligand interaction for almost all ligands available in Protein Data Bank.

::DEVELOPER

LPIcom team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web Browser

:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation

A web server for analysis, comparison and prediction of protein ligand binding sites.
Singh H, Srivastava HK, Raghava GP.
Biol Direct. 2016 Mar 25;11(1):14. doi: 10.1186/s13062-016-0118-5.

TFBSs 1.0 – Predicting Transcription Factor Binding Sites

TFBSs 1.0

:: DESCRIPTION

TFBSs is a web server for Predicting transcription factor binding sites.

::DEVELOPER

The Li’s Group of Theoretical Biophysics and Bioinformatics

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web Borowser

:: DOWNLOAD

  NO

:: MORE INFORMATION

Citation

Guo-liang Fan and Qianzhong Li, Keli Yang,
TFBSs: a web server for Predicting transcription factor binding sites.
2012 IEEE International Conference on Cyber Technology in Automation, Control, and Intelligent Systems (CYBER), 2012,1:65-68

P2Rank 2.0.1 – Protein-Ligand Binding Site prediction

P2Rank 2.0.1

:: DESCRIPTION

P2Rank is a machine learning based method for prediction of ligand binding sites from protein structure. P2Rank uses Random Forests classifier to infer ligandability of local chemical neighborhoods near the protein surface which are represented by specific near-surface points and described by aggregating physico-chemical features projected on those points from neighboring protein atoms. The points with high predicted ligandability are clustered and ranked to obtain the resulting list of binding site predictions.

::DEVELOPER

SIRET Research Group

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows/Linux
  • JRE 8 (Java 1.8) or JRE 11 (Java 11)
  • PyMOL

:: DOWNLOAD

P2Rank

:: MORE INFORMATION

Citation:

P2Rank: machine learning based tool for rapid and accurate prediction of ligand binding sites from protein structure.
Krivák R, Hoksza D.
J Cheminform. 2018 Aug 14;10(1):39. doi: 10.1186/s13321-018-0285-8.

SeqSite 1.0.0 – ChIP-Seq Binding Site Identification

SeqSite 1.0.0

:: DESCRIPTION

SeqSite was developed for detecting transcription factor binding sites from ChIP-seq data.SeqSite is an efficient and easy-to-use software tool implementing a novel method for identifying and pinpointing transcription factor binding sites. It first detects transcription factor binding regions by clustering tags and statistical hypothesis testing, and locates every binding site in detected binding regions by modeling the tag profiles. It can pinpoint closely spaced adjacent binding sites from ChIP-seq data.

::DEVELOPER

SeqSite team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux / Windows
  • C Compiler

:: DOWNLOAD

  SeqSite

:: MORE INFORMATION

Citation

Xi Wang and Xuegong Zhang.
Pinpointing transcription factor binding sites from ChIP-seq data with SeqSite.
BMC Systems Biology, 5(Suppl 2):S3.

MetalionRNA – Metal Ion Binding Site Predictor

MetalionRNA

:: DESCRIPTION

MetalionRNA is a novel bioinformatic method for predicting metal-binding sites in RNA structures.

::DEVELOPER

Bujnicki lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web browser

:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation

Computational methods for prediction of RNA interactions with metal ions and small organic ligands.
Philips A, Łach G, Bujnicki JM.
Methods Enzymol. 2015;553:261-85. doi: 10.1016/bs.mie.2014.10.057.

inSite – Interactive Viewer for Comparing Patterns of Binding Sites across multiple Genomics Regions

inSite

:: DESCRIPTION

inSite (interactive site viewer) is a tool for interactively visualizing binding sites along multiple genomic regions. Different types of transcription factors are encoded with color with a user-defined, interactive color legend.

::DEVELOPER

Miriah Meyer & DePace Lab

:: SCREENSHOTS

insite

:: REQUIREMENTS

  • Linux/ Windows/ MacOsX

:: DOWNLOAD

 inSite

:: MORE INFORMATION

BSG – Graphical Theoretical Prediction of Transcription Factor Binding Sites

BSG

:: DESCRIPTION

BSG is a collection of programs used to construct and analyze Binding Site Graphs. Overall,the analysis is a two step process that can be performed on separate computers. First, ensemble Gibbs sampling is performed, preferably on a massively parallel computer, and the results are collected. The resulting output files are then compressed (using gzip) to conserve disk space. Then, in a second step, the compressed output files are analyzed and predictions are made

::DEVELOPER

Bioinformatics and Evolution of Systems Laboratory

:: SCREENSHOTS

n/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 BSG

:: MORE INFORMATION

Citation

Timothy E Reddy, Charles DeLisi, Boris E Shakhnovich
Binding Site Graphs: A New Graph Theoretical Framework for Prediction of Transcription Factor Binding Sites
PLoS Comput Biol 3(5): e90. doi:10.1371/journal.pcbi.0030090

Protemot – Prediction of Protein Binding sites with automatically extracted Geometrical Templates

Protemot

:: DESCRIPTION

The Protemot (Protein motif) web server predicts protein binding sites based on the interaction templates automatically extracted from the compound crystals in the Protein Data Bank (PDB).

::DEVELOPER

Molecular Biomedical Informatics

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web Borowser

:: DOWNLOAD

  NO

:: MORE INFORMATION

Citation

Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W303-9.
Protemot: prediction of protein binding sites with automatically extracted geometrical templates.
Chang DT, Weng YZ, Lin JH, Hwang MJ, Oyang YJ.