BLASTO is a modified BLAST tool for searching orthologous group data. BLASTO treats each ortholog group as a unit, and instead of providing a ranked list of individual sequence hits, it organizes and ranks the BLAST results by ortholog groups, which is often a much more desirable format for functional inference or evolutionary studies.
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Nucleic Acids Res. 2007 Jul;35(Web Server issue):W678-82. Epub 2007 May 5.
BLASTO: a tool for searching orthologous groups.
Zhou Y, Landweber LF.