STAC 1.2
:: DESCRIPTION
STAC (Significance Testing for Aberrant Copy-Number) is a method for testing the significance of DNA copy number aberrations across multiple array-CGH experiments. It utilizes two complementary statistics in combination with a novel search strategy. The significance of both statistics is assessed, and P-values are assigned to each location on the genome by using a multiple testing corrected permutation approach. STAC identifies genomic alterations known to be of clinical and biological significance and provides statistical support for 85% of previously reported regions. Moreover, STAC identifies numerous additional regions of significant gain/loss in these data that warrant further investigation. The P-values provided by STAC can be used to prioritize regions for follow-up study in an unbiased fashion.
::DEVELOPER
the Computational Biology and Informatics Laboratory (in the Center for Bioinformatics at the University of Pennsylvania)
:: SCREENSHOTS
:: REQUIREMENTS
- Linux/ MacOsX / Windows
- Java
:: DOWNLOAD
:: MORE INFORMATION
Citation:
Diskin SJ, Eck T, Greshock J, Mosse YP, Naylor T, Stoeckert CJ Jr, Weber BL, Maris JM, Grant GR.
STAC: A method for testing the significance of DNA copy number aberrations across multiple array-CGH experiments
Genome Res. 2006 Sep;16(9):1149-58. Epub 2006 Aug 9.