Tag: Gene Silencing

MicroLive – Design of live attenuated Virus Vaccine based on microRNA-mediated Gene Silencing

MicroLive

:: DESCRIPTION

MicroLive (μLIVE) web server provides virologists a simple web interface to design human-specific microRNA response elements (MREs). There MREs could be incorporated into the open reading frames (ORFs) of RNA viral sequences to increase attenuation and improve safety for the live attenuated virus (LAV) vaccines, based on miRNA-mediated gene silencing

::DEVELOPER

Information Systems Laboratory at BIOTEC

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web Browser

:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation

Duangdao Wichadakul, Wuttichai Mhuantong, Anan Jongkaewwattana and Supawadee Ingsriswang (2012),
“A computational tool for the design of live attenuated virus vaccine based on microRNA-mediated gene silencing“,
BMC Genomics 2012, 13(Suppl 7):S15

microDoR – Prediction of Human miRNA-Mediated Gene Silencing

microDoR

:: DESCRIPTION

microDoR Human is an online machine learning algorithm based on SVM (support vector machine) to predict Human miRNA-mediated gene silencing: mRNA degradation or translational repression, and it can also determine whether a mRNA is a target of a miRNA according to Pictar and PITA.

::DEVELOPER

microDoR team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web browser

:: DOWNLOAD

  NO

:: MORE INFORMATION

Citation

Comput Biol Med. 2012 Jan;42(1):1-7. doi: 10.1016/j.compbiomed.2011.10.001.
Predicting miRNA-mediated gene silencing mode based on miRNA-target duplex features.
Song X1, Cheng L, Zhou T, Guo X, Zhang X, Chen YP, Han P, Sha J.