grnl1 – Gene Regulatory Network modeling using L1 Regularized Graphical Models

grnl1

:: DESCRIPTION

grnl1 is a software of gene regulatory network modeling using L1 regularized graphical models

::DEVELOPER

grnl1 team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux / Windows /MacOsX
  • C Compiler

:: DOWNLOAD

 grnl1

:: MORE INFORMATION

Citation

PLoS One. 2012;7(5):e35762. doi: 10.1371/journal.pone.0035762. Epub 2012 May 7.
Learning transcriptional regulatory relationships using sparse graphical models.
Zhang X1, Cheng W, Listgarten J, Kadie C, Huang S, Wang W, Heckerman D.

REDUCE 1.0 – Optimal Design of Gene Knock-out (KO) for the purpose of Gene Regulatory Network (GRN) Inference

REDUCE 1.0

:: DESCRIPTION

REDUCE (REDuction of UnCertain Edges) is an algorithm for finding the optimal gene KO experiment for inferring directed graphs (digraphs) of gene regulatory network (GRN).

:: DEVELOPER

Chemical and Biological Systems Engineering Laboratory

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux / windows/ MacOsX
  • MatLab

:: DOWNLOAD

 REDUCE

:: MORE INFORMATION

Citation

Optimal design of gene knock-out experiments for gene regulatory network inference.
Ud-Dean SM, Gunawan R.
Bioinformatics. 2015 Nov 14. pii: btv672

CN – Inferring Gene Regulatory Networks using SORDER algorithm

CN

:: DESCRIPTION

CN (Consensus Network) is a network inference method based on the SORDER algorithm and a suitable interval threshold for Conditional Mutual Information (CMI) tests

::DEVELOPER

School of Biological Sciences, Iran

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows/ Linux / MacOsX
  • MatLab

:: DOWNLOAD

 CN

:: MORE INFORMATION

Citation

CN: a consensus algorithm for inferring gene regulatory networks using the SORDER algorithm and conditional mutual information test.
Aghdam R, Ganjali M, Zhang X, Eslahchi C.
Mol Biosyst. 2015 Mar;11(3):942-9. doi: 10.1039/c4mb00413b

IPCA-CMI – Inferring Gene Regulatory Networks based on Combination of PCA-CMI and MIT score

IPCA-CMI

:: DESCRIPTION

IPCA-CMI is an algorithm for inferring gene regulatory networks based on a combination of PCA-CMI and MIT score.

::DEVELOPER

School of Biological Sciences, Iran

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows/ Linux / MacOsX
  • MatLab

:: DOWNLOAD

 IPCA-CMI

:: MORE INFORMATION

Citation

PLoS One. 2014 Apr 11;9(4):e92600. doi: 10.1371/journal.pone.0092600. eCollection 2014.
IPCA-CMI: an algorithm for inferring gene regulatory networks based on a combination of PCA-CMI and MIT score.
Aghdam R1, Ganjali M1, Eslahchi C

LDGM – Identifying Gene Regulatory Network Rewiring using Latent Differential Graphical Models

LDGM

:: DESCRIPTION

LDGM estimates differential network between two tissue types directly without inferring the network for individual tissues.

::DEVELOPER

Ma Laboratory

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux / Windows / MacOsX
  • Matlab

:: DOWNLOAD

LDGM

:: MORE INFORMATION

Citation

Nucleic Acids Res. 2016 Sep 30;44(17):e140. doi: 10.1093/nar/gkw581.
Identifying gene regulatory network rewiring using latent differential graphical models.
Tian D, Gu Q, Ma J.

ModEnt – Reconstructing Gene Regulatory Networks

ModEnt

:: DESCRIPTION

ModEnt is a computational tool that reconstructs gene regulatory networks from high throughput experimental data.

::DEVELOPER

Ron Shamir’s lab

:: SCREENSHOTS

N/A

::REQUIREMENTS

  • Windows/Linux

:: DOWNLOAD

 ModEnt

:: MORE INFORMATION

Citation

Karlebach, G. and Shamir, R.,
Constructing logical models of gene regulatory networks by integrating transcription factor-DNA interactions with expression data: an entropy based approach.
Journal of Computational Biology.2012 Jan;19(1):30-41.

GPODE 20090927 – Learning Gene Regulatory Networks from Gene Expression Measurements

GPODE 20090927

:: DESCRIPTION

GPODE (GP4GRN) is a software of learning the structure of gene regulatory networks using non-parametric molecular kinetics. A set of Matlab functions that implement our gene regulatory network inference method. The method can use time-series and steady state gene expression (and protein) measurements and makes Bayesian inference for the network structure using Gaussian process based non-parametric molecular kinetics

::DEVELOPER

Tarmo Äijö

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux/ MacOsX / Windows
  • Matlab

:: DOWNLOAD

 GPODE

:: MORE INFORMATION

Citation:

Bioinformatics. 2009 Nov 15;25(22):2937-44. Epub 2009 Aug 25.
Learning gene regulatory networks from gene expression measurements using non-parametric molecular kinetics.
Aijö T, Lähdesmäki H.

geneDBN V01.9R01 – Build Gene Regulatory Networks

geneDBN V01.9R01

:: DESCRIPTION

geneDBN is a software to build gene regulatory networks based on DBN (dynamic Bayesian network).

::DEVELOPER

Complex Computation Laboratory ,Iowa State University

:: SCREENSHOTS

Command Line

:: REQUIREMENTS

  • Windows

:: DOWNLOAD

Registration First ; geneDBN

:: MORE INFORMATION

Copyright (C) 2007 Song Li and Hui-Hsien Chou.Bug report and suggestions are welcome and can be sent to geneDBN@www.complex.iastate.edu.

 

 

SpotXplore 20100804 – Cytoscape plugin for Visual Exploration of Hotspot Expression in Gene Regulatory Networks

SpotXplore 20100804

:: DESCRIPTION

SpotXplore is a plug-in for Cytoscape which enhances the visual analysis of gene expression obtained by, e.g., microarrays or the newer RNA-seq techniques in various ways. It enables visualization of multiple conditions or time series by glyphs that encode both expression value and statistical confidence.

::DEVELOPER

Dr. Michel A. Westenberg

:: SCREENSHOTS

:: REQUIREMENTS

:: DOWNLOAD

 SpotXplore

:: MORE INFORMATION

Citation

M. A. Westenberg, J. B. T. M. Roerdink, O. P. Kuipers, S. A. F. T. van Hijum.
SpotXplore: a Cytoscape plugin for visual exploration of hotspot expression in gene regulatory networks.
Bioinformatics, 26(22):2922-2923, 2010.

GRNInfer 1.0 – Gene Regulatory Network Inference tool from multiple microarray datasets

GRNInfer 1.0

:: DESCRIPTION

GRNInfer aims to derive the most consistent network structure with respect to Multiple Microarray Datasets, by exploiting available information from a variety of experiments. Specifically, inferring gene network is formulated as an optimization problem with minimization of L1 norm for the objective function, which involves both forced matching and sparse terms. An efficient algorithm is developed to solve such a large-scale linear programming in an iterative manner. With such a procedure, a consistent and sparse structure that is also considered to be biologically plausible, can be expected to be derived.

::DEVELOPER

APORC

:: SCREENSHOTS

:: REQUIREMENTS

  • Windows

:: DOWNLOAD

  GRNInfer

:: MORE INFORMATION

Citation

Yong Wang, Trupti Joshi, Xiang-Sun Zhang, Dong Xu, and Luonan Chen.
Inferring gene regulatory networks from multiple microarray datasets.
Bioinformatics, Vol. 22, No. 19, pp. 2413-2420, 2006.