:: DESCRIPTION
ERC measures correlated rates across a phylogeny, allowing for extraction of genes with similar evolutionary histories.
::DEVELOPER
Department of Computational and Systems Biology , University of Pittsburgh
:: SCREENSHOTS
N/A
:: REQUIREMENTS
:: DOWNLOAD
NO
:: MORE INFORMATION
Citation:
ERC analysis: web-based inference of gene function via evolutionary rate covariation.
Wolfe NW, Clark NL.
Bioinformatics. 2015 Aug 4. pii: btv454.
:: DESCRIPTION
GERP++ (Genomic Evolutionary Rate Profiling) identifies constrained elements in multiple alignments by quantifying substitution deficits. These deficits represent substitutions that would have occurred if the element were neutral DNA, but did not occur because the element has been under functional constraint.
::DEVELOPER
:: SCREENSHOTS
N/A
:: REQUIREMENTS
:: DOWNLOAD
:: MORE INFORMATION
Citation
PLoS Comput Biol. 2010 Dec 2;6(12):e1001025.
Identifying a high fraction of the human genome to be under selective constraint using GERP++.
Davydov EV, Goode DL, Sirota M, Cooper GM, Sidow A, Batzoglou S.