eCAMI is a Python package: (i) has the best performance in terms of accuracy and memory use for CAZyme and enzyme EC classification and annotation; (ii) the k-mer-based tools (including PPR-Hotpep, CUPP and eCAMI) perform better than homology-based tools and deep-learning tools in enzyme EC prediction.
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Xu J, Zhang H, Zheng J, Dovoedo P, Yin Y.
eCAMI: simultaneous classification and motif identification for enzyme annotation.
Bioinformatics. 2020 Apr 1;36(7):2068-2075. doi: 10.1093/bioinformatics/btz908. PMID: 31794006.