Tag: Disease Gene

Phaser 20130408 – Disease Gene Identification by Haplotype Reconstruction

Phaser 20130408

:: DESCRIPTION

Phaser is a program for the rapid identification of linkage to recessive disease genes in either consanguineous or out-bred families, by reconstructing the haplotype for each individual’s chromosomes within a pedigree

::DEVELOPER

Ian’s DNA@Leeds

:: SCREENSHOTS

Phaser

:: REQUIREMENTS

  • Windows
  • Microsoft .NET framework version 2.0

:: DOWNLOAD

 Phaser

:: MORE INFORMATION

Citation

Carr IM, Diggle DP, Touqan N, Anwar R, Sheridan EG, Bonthron DT, Johnson CA, Ali M, Markham AF.
Identification of autosomal recessive disease loci using out-bred nuclear families.
Hum Mutat. 2012 Feb;33(2):338-42.

CIPHER – Correlating Protein Interaction Network and Phenotype Network to predict Disease Genes

CIPHER

:: DESCRIPTION

CIPHER, which stands for Correlating interactome and phenome networks to predict disease genes, is a computational framework we proposed to prioritize human disease genes. It was one of the first studies to explore interactome-phenome wide gene-disease relationships, and generated the first comprehensive genetic landscape of human disease,connecting 5080 human disease phenotypes with 14433 human genes.

::DEVELOPER

Wu Lab @ Columbia

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • MatLab

:: DOWNLOAD

NO

 :: MORE INFORMATION

Citation:

Mol Syst Biol. 2008;4:189. doi: 10.1038/msb.2008.27. Epub 2008 May 6.
Network-based global inference of human disease genes.
Wu X1, Jiang R, Zhang MQ, Li S.