SPRUCE

:: DESCRIPTION

SPRUCE is an algorithm that infers a multi-state perfect phylogeny describing the evolutionary history of the somatic mutations (SNVs and CNVs) of a tumor given multi-sample bulk sequencing data. Specifically, the input to SPRUCE are variant allele frequencies and copy-number mixing proportions for each SNV in each sample.

::DEVELOPER

Raphael Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

• Linux
• C++

:: DOWNLOAD

SPRUCE

:: MORE INFORMATION

Citation:

El-Kebir M, Satas G, Oesper L, Raphael BJ.
Inferring the Mutational History of a Tumor Using Multi-state Perfect Phylogeny Mixtures.
Cell Syst. 2016 Jul;3(1):43-53. doi: 10.1016/j.cels.2016.07.004. PMID: 27467246.