QuadGT
:: DESCRIPTION
QuadGT is a software package for calling single-nucleotide variants in four sequenced genomes comprising a normal-tumor pair and the two parents. Genotypes are inferred using a joint model of parental variant frequencies, de novo germline mutations, and somatic mutations. The model quantifies the descent-by-modification relationships between the unknown genotypes by using a set of parameters in a Bayesian inference setting.
::DEVELOPER
Eric Bareke and Miklós Csűrös.
:: SCREENSHOTS
:: REQUIREMENTS
- MacOsX / Linux /Windows
- Java
- SAMTools
:: DOWNLOAD
:: MORE INFORMATION
Citation
BMC Bioinformatics. 2013;14 Suppl 5:S3. doi: 10.1186/1471-2105-14-S5-S3. Epub 2013 Apr 10.
Joint genotype inference with germline and somatic mutations.
Bareke E, Saillour V, Spinella JF, Vidal R, Healy J, Sinnett D, Csűrös M.