PATHiWAYS is a web tool for the interpretation of the consequences of the combined changes in expression levels of genes in the context of signaling pathways. Specifically, this tool allows the user to identify the stimulus-response subpathways that are significantly activated or deactivated in the typical case/control experiment. PATHiWAYS identifies all the stimulus-response subpathways of KEGG signaling pathways, calculates the probability of activation of each one, based on the individual gene expression values and identifies those with a significant differential activity between the two conditions compared.
the Computational Biology Unit, at Computational Medicine Institute at CIPF in Valencia, Spain.
- Web Browser
:: MORE INFORMATION
Nucleic Acids Res. 2013 Jul;41(Web Server issue):W213-7. doi: 10.1093/nar/gkt451. Epub 2013 Jun 8.
Inferring the functional effect of gene expression changes in signaling pathways.
Sebastián-León P1, Carbonell J, Salavert F, Sanchez R, Medina I, Dopazo J.