The GPCR-CA (G-protein-coupled receptor – Cellular Automaton) is a 2-layer predictor: the 1st layer prediction engine is for identifying a query protein sequence as GPCR on non-GPCR; if it is a GPCR protein, the process will be automatically continued with the 2nd-layer prediction engine to further identify its type among the following six main functional classes: (1) rhodopsin-like, (2) secretin-like, (3) metabotrophic/glutamate/pheromone, (4) fungal pheromone, (5) cAMP receptor, and (6) Frizzled/Smoothemed family
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GPCR-CA: A cellular automaton image approach for predicting G-protein-coupled receptor functional classes.
Xiao X, Wang P, Chou KC.
J Comput Chem. 2009 Jul 15;30(9):1414-23. doi: 10.1002/jcc.21163.