EBCall – Empirical Bayesian framework for Mutation Detection from Cancer Genome Sequencing data

EBCall

:: DESCRIPTION

EBCall (Empirical Bayesian mutation Calling) is a software package for somatic mutation detection (including InDels). EBCall uses not only paired tumor/normal sequence data of a target sample, but also multiple non-paired normal reference samples for evaluating distribution of sequencing errors, which leads to an accurate mutaiton detection even in case of low sequencing depths and low allele frequencies.

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::DEVELOPER

Yuichi Shiraishi (yshira@hgc.jp) ,Kenichi Chiba

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • samtools
  • R package
  • C++ Compiler
  • The VGAM package for R

:: DOWNLOAD

 EBCall

:: MORE INFORMATION

Citation

Nucleic Acids Res. 2013 Apr;41(7):e89. doi: 10.1093/nar/gkt126. Epub 2013 Mar 6.
An empirical Bayesian framework for somatic mutation detection from cancer genome sequencing data.
Shiraishi Y, Sato Y, Chiba K, Okuno Y, Nagata Y, Yoshida K, Shiba N, Hayashi Y, Kume H, Homma Y, Sanada M, Ogawa S, Miyano S.