DISCERN
:: DESCRIPTION
Discern is a method for catalytic residue prediction derived from the combination of three ingredients: the use of the INTREPID phylogenomic method to extract conservation information; the use of 3D structure data, including features computed for residues that are proximal in the structure; and a statistical regularization procedure to prevent overfitting.
::DEVELOPER
the Berkeley Phylogenomics Group
:: SCREENSHOTS
N/A
:: REQUIREMENTS
- Linux
- Perl
- Python
:: DOWNLOAD
:: MORE INFORMATION
Citation
Sankararaman, S., Sha, F., Kirsch, J.F., Jordan, M.I., and Sjölander, K.,
Active Site Prediction using Evolutionary and Structural Information
Bioinformatics (2010) 26 (5): 617-624.; doi: 10.1093/bioinformatics/btq008