CIRCLET

:: DESCRIPTION

CIRCLET is a powerful and robust circular trajectory reconstruction tool without specifying a starting cell for resolving cell cycle phases of single cells by considering multi-scale features of chromosomal architectures. CIRCLET reveals its best superiority based on the combination of a feature set about global information and two feature sets about local interactional information in terms of designed evaluation indexes and verification strategies from a collection of cell cycle Hi-C maps.

::DEVELOPER

Shihua Zhang’s Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

• Windows/Linux
• Python

:: DOWNLOAD

CIRCLET

:: MORE INFORMATION

Citation

Ye Y, Gao L, Zhang S.
Circular Trajectory Reconstruction Uncovers Cell-Cycle Progression and Regulatory Dynamics from Single-Cell Hi-C Maps.
Adv Sci (Weinh). 2019 Sep 30;6(23):1900986. doi: 10.1002/advs.201900986. PMID: 31832309; PMCID: PMC6891923.