Expression levels of mRNAs are among other factors regulated by microRNAs. A particular microRNA can bind specifically to several target mRNAs and lead to their degradation. Expression levels of both, mRNAs and microRNAs, can be obtained by microarray experiments. In order to increase the power of detecting microRNAs that are differentially expressed between two different groups of samples, “miRtest” incorporates expression levels of their related target gene sets.
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PLoS One. 2012;7(6):e38365. doi: 10.1371/journal.pone.0038365. Epub 2012 Jun 19.
Detection of simultaneous group effects in microRNA expression and related target gene sets.
Artmann S1, Jung K, Bleckmann A, Beissbarth T.