Chandak S, Tatwawadi K, Ochoa I, Hernaez M, Weissman T. SPRING: a next-generation compressor for FASTQ data.
Bioinformatics. 2019 Aug 1;35(15):2674-2676. doi: 10.1093/bioinformatics/bty1015. PMID: 30535063; PMCID: PMC6662292.
SPRING is a template-base algorithm for protein-protein structure prediction. It first threads one chain of the protein complex through the PDB library with the binding parters retrieved from the original oligomer entries. The complex models associated with another chain is deduced from a pre-calculated look-up table, with the best orientation selected by the SPRING-score which is a combination of threading Z-score, interface contacts, and TM-align match between monomer-to-dimer templates.