PHYLIP (the PHYLogeny Inference Package) is a free package of programs for inferring phylogenies (evolutionary trees). It is distributed as source code, documentation files, and a number of different types of executables.
CBCAnalyzer ( compensatory base change) is a custom written software toolbox consisting of three parts, CTTransform, CBCDetect, and CBCTree. CTTransform reads several CT-file formats (ct, RNAviz ct or Mac ct), and generates a so called “bracket-dot-bracket” format that typically is used as input for other tools such as RNAforester, RNAmovie or MARNA. The latter one creates a multiple alignment based on primary sequences and secondary structures that now can be used as input for CBCDetect. Herewith we count for CBCs in all against all of the aligned sequences, which is important in detecting species, discriminated on their sexual incompatibility. The count (distance) matrix obtained by CBCDetect is used as input for CBCTree that reconstructs a phylogram by using the algorithm of BIONJ.