ASGAL v1.1.6 – Alternative Splicing Graph ALigner

ASGAL v1.1.6

:: DESCRIPTION

ASGAL is a tool for detecting the alternative splicing events expressed in a RNA-Seq sample with respect to a gene annotation.

::DEVELOPER

AlgoLab

:: SCREENSHOTS

N/A

::REQUIREMENTS

  • Linux
  • Python

:: DOWNLOAD

ASGAL

:: MORE INFORMATION

Citation

Denti L, Rizzi R, Beretta S, Vedova GD, Previtali M, Bonizzoni P.
ASGAL: aligning RNA-Seq data to a splicing graph to detect novel alternative splicing events.
BMC Bioinformatics. 2018 Nov 20;19(1):444. doi: 10.1186/s12859-018-2436-3. PMID: 30458725; PMCID: PMC6247705.

RepeatExplorer2 0.3.8 – Repeat Discovery and Characterization using Graph based Sequence Clustering

RepeatExplorer2 0.3.8

:: DESCRIPTION

RepeatExplorer is a computational pipeline designed to identify and characterize repetitive DNA elements in next-generation sequencing data from plant and animal genomes.

TAREAN (TAndem REpeat ANalyzer) is a computational pipeline for unsupervised identification of satellite repeats from unassembled sequence reads. The pipeline uses low-pass whole genome sequence reads and performs their graph-based clustering. Resulting clusters, representing all types of repeats, are then examined for the presence of circular structures and putative satellite repeats are reported.

::DEVELOPER

Laboratory of Molecular Cytogenetics

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

RepeatExplorer2

:: MORE INFORMATION

Citation

Novák P, Ávila Robledillo L, Koblížková A, Vrbová I, Neumann P, Macas J.
TAREAN: a computational tool for identification and characterization of satellite DNA from unassembled short reads.
Nucleic Acids Res. 2017 Jul 7;45(12):e111. doi: 10.1093/nar/gkx257. PMID: 28402514; PMCID: PMC5499541.

Novák P, Neumann P, Macas J.
Global analysis of repetitive DNA from unassembled sequence reads using RepeatExplorer2.
Nat Protoc. 2020 Nov;15(11):3745-3776. doi: 10.1038/s41596-020-0400-y. Epub 2020 Oct 23. PMID: 33097925.

SeqGrapheR 0.5.2.4 – Graph based Visualization of Cluster of DNA sequence reads

SeqGrapheR 0.5.2.4

:: DESCRIPTION

 SeqGrapheR package provide interactive GUI for visualization of DNA sequence clusters.

::DEVELOPER

Laboratory of Molecular Cytogenetics

:: SCREENSHOTS

:: REQUIREMENTS

  • Linux / Windows / MacOsX
  • R package

:: DOWNLOAD

 SeqGrapheR

:: MORE INFORMATION

Citation

Graph-based clustering and characterization of repetitive sequences in next-generation sequencing data
Petr Novák, Pavel Neumann and Jiří Macas
BMC Bioinformatics 2010, 11:378

iARG – Imperfect Ancestral Recombination Graph Reconstruction

iARG

:: DESCRIPTION

iARG is a collection of tools to reconstruct evolutionary histories which include recombination and back/recurrent mutation events.

::DEVELOPER

The Istrail Laboratory of Brown University

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • Perl
  • C++ Compiler

:: DOWNLOAD

 iARG

:: MORE INFORMATION

Citation

J Comput Biol. 2010 Jun;17(6):767-81. doi: 10.1089/cmb.2009.0249.
The imperfect ancestral recombination graph reconstruction problem: upper bounds for recombination and homoplasy.
Lam F1, Tarpine R, Istrail S.

SpliceDB 1.0 – Splice Graph Proteomics Tools

SpliceDB 1.0

:: DESCRIPTION

SpliceDB is a software of incorporation of RNA-seq for MS database search

::DEVELOPER

CCMS The Center for Computational Mass Spectrometry

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux/ Windows/ MacOsX
  • Java

:: DOWNLOAD

 SpliceDB

:: MORE INFORMATION

Citation

J Proteome Res. 2014 Jan 3;13(1):21-8. doi: 10.1021/pr400294c. Epub 2013 Jul 17.
Proteogenomic database construction driven from large scale RNA-seq data.
Woo S1, Cha SW, Merrihew G, He Y, Castellana N, Guest C, MacCoss M, Bafna V.

MEGAHIT v1.2.9 – Large and Complex Metagenomics Assembly via Succinct de Bruijn graph

MEGAHIT v1.2.9

:: DESCRIPTION

MEGAHIT is a single node assembler for large and complex metagenomics NGS reads, such as soil. It makes use of succinct de Bruijn graph to achieve low memory usage, whereas its goal is not to make memory usage as low as possible.

::DEVELOPER

Dinghua Li

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux / MacOsX
  • Python
  • G++

:: DOWNLOAD

 MEGAHIT

:: MORE INFORMATION

Citation

MEGAHIT: An ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph.
Li D, Liu CM, Luo R, Sadakane K, Lam TW.
Bioinformatics. 2015 Jan 20. pii: btv033.

GraPPLE – Graph Property based Predictor and Likelihood Estimator

GraPPLE

:: DESCRIPTION

GraPPLE are abstract representations of relationships between entities. Through a set of instructions, they are able to convert relationships into nodes and edges. GraPPLE (originally: The RNA sorting hat) leverages the information available from graph properties and the predictive power of support vector machines (SVMs) to classify potential RNA sequences as functional/non-functional and into 1 of 46 Rfam families. In short, GraPPLE predicts the potential function of an ncRNA sequence.

::DEVELOPER

Max Planck Institute for Molecular Plant Physiology

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web Browser

:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation

Nucleic Acids Res. 2009 May;37(9):e66. Epub 2009 Apr 1.
Identification and classification of ncRNA molecules using graph properties.
Childs L, Nikoloski Z, May P, Walther D.

Graph 1.0 – Constructs, Visualizes and Modifies Graphs

Graph 1.0

:: DESCRIPTION

Graph constructs, visualizes and modifies graphs as well as calculates measures and layouts

::DEVELOPER

The Microsoft Research – University of Trento Centre for Computational and Systems Biology

:: SCREENSHOTS

:: REQUIREMENTS

  • Windows
  • .NET Framework

:: DOWNLOAD

 Graph

:: MORE INFORMATION

Citation

Roberto Valentini, Ferenc Jordan.
COSBILab Graph: the network analysis module of COSBILab Environmental Modelling and Software, 25:886-888, 2010

GRAPES 2.9 – SMP Querying system for Efficient Parallel Subgraph Isomorphism in databases of Graphs

GRAPES 2.9

:: DESCRIPTION

GRAPES is a querying system for parallel searching in databases of graphs, and single target graph, using symmetric multiprocessing (SMP) architectures. It implements a parallel version of well established graph searching algorithms providing efficient solutions for graphs indexing and matching.

::DEVELOPER

Alfredo Pulvirenti

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 GRAPES

:: MORE INFORMATION

Citation:

GRAPES: a software for parallel searching on biological graphs targeting multi-core architectures.
Giugno R, Bonnici V, Bombieri N, Pulvirenti A, Ferro A, Shasha D.
PLoS One. 2013 Oct 22;8(10):e76911. doi: 10.1371/journal.pone.0076911.

Recycler v0.7 – Detecting Plasmids from de novo Assembly Graphs

Recycler v0.7

:: DESCRIPTION

Recycler is a tool for extracting cyclical sequences from assembly graphs that are likely to be plasmids, phages, or other mobile elements that are physically separate from their host genomes. It can be applied on isolate, metagenome, and plasmidome graphs.

::DEVELOPER

Ron Shamir’s lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • Python

:: DOWNLOAD

Recycler

:: MORE INFORMATION

Citation

Bioinformatics. 2017 Feb 15;33(4):475-482. doi: 10.1093/bioinformatics/btw651.
Recycler: an algorithm for detecting plasmids from de novo assembly graphs.
Rozov R, Brown Kav A, Bogumil D, Shterzer N, Halperin E, Mizrahi I, Shamir R.

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