MNI
:: DESCRIPTION
The MNI (Mode-of-action by Network Inference ) is an algorithm to identify the gene targets of a drug treatment based on gene-expression data. In a typical use of the algorithm, a single expression profile, say obtained as a result of a treatment under study, is used as the test profile while a set of hundreds of expression profiles is used as the training set. The MNI algorithm uses the large training data set of expression profiles to construct a statistical model of gene-regulatory networks in a cell or tissue. The model describes combinatorial influences of genes on one another.
::DEVELOPER
:: SCREENSHOTS
N/A
:: REQUIREMENTS
- Linux / Windows / MacOsX
- MatLab
:: DOWNLOAD
:: MORE INFORMATION
Citation
Nat Protoc. 2006;1(6):2551-4.
The mode-of-action by network identification (MNI) algorithm: a network biology approach for molecular target identification.
Xing H, Gardner TS.