urms – Structure Comparison Algorithm

urms

:: DESCRIPTION

urms (unit-vector root mean squared)  is a protein structure comparison program that compares two structures (in PDB format).

::DEVELOPER

Golan Yona

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 urms

:: MORE INFORMATION

Citation

Golan Yona and Klara Kedem. (2005).
The URMS-RMS hybrid algorithm for fast and sensitive local protein structure alignment.
Journal of Computational Biology 12 12-32.

prof_sim – Profile-profile Comparison Algorithm

prof_sim

:: DESCRIPTION

prof_sim is a profile-profile comparison program that compares PSI-BLAST profiles.

::DEVELOPER

Golan Yona

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux / MacOsX

:: DOWNLOAD

 prof_sim

:: MORE INFORMATION

Citation

Golan Yona and Michael Levitt.
Within the twilight zone: A sensitive profile-profile comparison tool based on information theory. (2002).
Journal of Molecular Biology 315 1257-1275.

COMPASS 3.1 – COmparison of Multiple Protein Sequence Alignments with assessment of Statistical Significance.

COMPASS 3.1

:: DESCRIPTION

COMPASS runs a search with submitted alignment (or sequence) as a query against a database of protein families.

::DEVELOPER

Grishin Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 COMPASS

:: MORE INFORMATION

Citation:

R.I. Sadreyev, M. Tang, B. Kim and N.V. Grishin (2009)
COMPASS server for homology detection: improved statistical accuracy, speed, and functionality.
Nucleic Acids Res doi:10.1093/nar/gkp360.

MS_Align 2.0 – Comparison of Minisatellites

MS_Align 2.0

:: DESCRIPTION

MS_Align is a soft ware of comparison of minisatellites.

::DEVELOPER

Bérard S, Rivals E.

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  •  Linux / MacOsX

:: DOWNLOAD

  MS_Align

:: MORE INFORMATION

Citation

Comparison of minisatellites.”
Bérard S., Rivals E.
Journal of Computational Biology. 2003 10(3-4):357-72.

 

RNACluster 1.0 – RNA Secondary Structure Comparison and Clustering

RNACluster 1.0

:: DESCRIPTION

RNACluster is an integrated computational software which implements 6 common structure distances to measure the (dis)similarity of RNA secondary structures including base pair distance, mountain distance, morphological distance, tree edit distance, string edit distance and our in-house structure matrix distance, and one effective cluster approach for the ensemble clustering using a minimum spanning tree (MST) based algorithm. RNACluster can be used to study the characteristics of RNA secondary structures, RNA structure conformational switches, RNA conformational energy landscapes and RNA secondary structure prediction based on the clustering of structure ensemble.

::DEVELOPER

Qi Liu

:: REQUIREMENTS

  • Linux/Windows

:: DOWNLOAD

 RNACluster

:: MORE INFORMATION

Citation

Liu Q, Olman V, Liu H, Ye X, Qiu S, Xu Y.
RNACluster: An integrated tool for RNA secondary structure comparison and clustering.
J Comput Chem. 2008 Jul 15;29(9):1517-26.

MUTPROF 0.2 / MUTCOMP 0.1 – Comparison of Mutation Profiles

MUTPROF 0.2 / MUTCOMP 0.1

:: DESCRIPTION

MUTPROF is a Monte-Carlo-Markov-Chain implementation of the hypergeometric test for sparse 3-dimensional contingency tables (in the spirit of Fisher’s exact test). It allows the comparison of up to 200 positions within the same gene, but between different tissues and/or species.

MUTCOMP serves to compare two nucleotide substitution matrices for one or more, possibly different genes, tissues or species, taking the expected mutation frequencies into account.

::DEVELOPER

 Michael Krawczak

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows

:: DOWNLOAD

  MUTPROF / MUTCOMP

:: MORE INFORMATION

GSC 1.2 – NMR Chemical Shift Comparison

GSC 1.2

:: DESCRIPTION

GSC is a tcl/tk program which makes it easy to analyze chemical shifts of selected atoms between chemical shift files

::DEVELOPER

Brian Sykes Lab

:: SCREENSHOTS

:: REQUIREMENTS

:: DOWNLOAD

 GSC

:: MORE INFORMATION

Citation

Wolfram Gronwald , R. Boyko, and B.D. Sykes.
GSC: a graphical program for NMR chemical shifts comparison
Comput Appl Biosci (1997) 13 (5): 557-558

STRuster 3.1 – Comparison and Analysis of Alternative Structural Models

STRuster 3.1

:: DESCRIPTION

STRuster is a method for clustering alternative structural models corresponding to different structure determination experiments. Alternative structural models, determined by X-ray crystallography or NMR spectroscopy, are frequently available for a given protein. These models can present significant structural dissimilarity.  The structures are classified according to backbone structure similarity.

::DEVELOPER

Francisco S. Domingues , Max-Planck-Institut Informatik

:: SCREENSHOTS

N/A

:: REQUIREMENTS

:: DOWNLOAD

STRuster

:: MORE INFORMATION

Citation:

Domingues, F. S.; Rahnenfuhrer, J.; Lengauer, T.,
Conformational analysis of alternative protein structures.
Bioinformatics 2007, 23 (23), 3131-8.

CLICK – Comparison of Biomolecular 3D Structures

CLICK

:: DESCRIPTION

CLICK is capable of superimposing the 3D structures of biomolecules, the Cartesian coordinates of whose constituent atoms are presented in the PDB format. In addition to coordinates, the web server can make use of similarity of other structural features such as secondary structure, solvent accessible surface area, and residue depth to guide the alignment. CLICK first looks for cliques of points (3–7 residues) that are structurally similar in the pair of structures to be aligned. Using these local similarities, a one-to-one equivalence is charted between the residues of the two structures. A least square fit then superimposes the two structures. Our method is especially powerful in establishing protein relationships by detecting similarities in structural subdomains, domains and topological variants.

CLICK Online Version

::DEVELOPER

Bioinformatics Institute of Singapore.

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 CLICK

:: MORE INFORMATION

Citation:

Nguyen,M.N., Tan,K.P., and Madhusudhan,M.S. (2011)
CLICK – Topology independent comparison of biomolecular 3D structures.
Nucleic Acids Res., doi:10.1093/nar/gkr393

CMap 1.01 – View Comparisons of Genetic & Physical Maps

CMap 1.01

:: DESCRIPTION

CMap (omparative Map Viewer) is a web-based tool that allows users to view comparisons of genetic and physical maps. The package also includes tools for curating map data. A user can compare an unlimited number of maps, view pair-wise comparisons of known correspondences, and search for maps or for features by name, species, type and accession. CMap is freely available, can run on a variety of database engines and uses only free and open software components.

::DEVELOPER

the Generic Model Organism Database

:: SCREENSHOTS

:: REQUIREMENTS

  • Windows / Mac OsX / Linux /
  • Perl 5.6.0 or higher
  • web server with CGI capabilites (e.g., Apache 1.x or 2.x)
  • A relational database, e.g. MySQL (4.0+), Sybase Adaptive Server Enterprise, PostgreSQL, SQLite or Oracle (9.x)
  • libgd 2.0.28 and GD.pm 2.15
  • Various Perl modules available on CPAN

:: DOWNLOAD

CMap ;  Documation

:: MORE INFORMATION

Citation

Ken Youens-Clark, Ben Faga, Immanuel V. Yap, Lincoln Stein and Doreen Ware
CMap 1.01: a comparative mapping application for the Internet.
, Bioinformatics 2009 25(22):3040-3042; doi:10.1093/bioinformatics/btp458.

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