Tag: care

CARE – Computational Analysis of REsistance

CARE

:: DESCRIPTION

CARE is a software developed to enable large-scale inference of response biomarkers and drug combinations for targeted therapies using compound screen data.

::DEVELOPER

X. Shirley Liu Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

CARE

:: MORE INFORMATION

Citation

Cell Syst. 2018 Mar 28;6(3):343-354.e5. doi: 10.1016/j.cels.2018.01.009.
Genome-Scale Signatures of Gene Interaction from Compound Screens Predict Clinical Efficacy of Targeted Cancer Therapies.
Jiang P, Lee W, Li X, Johnson C, Liu JS, Brown M5 Aster JC, Liu XS.

care 1.1.10 – High-Dimensional Regression and CAR Score Variable Selection

care 1.1.10

:: DESCRIPTION

The “care” package a novel multivariate algorithm for large scale SNP selection using CAR score regression, a promising new approach for prioritizing biomarkers.  CAR scores measure the correlation between the response and the Mahalanobis-decorrelated predictors. The squared CAR score is a natural measure of variable importance and provides a canonical ordering of variables. This package provides functions for estimating CAR scores, for variable selection using CAR scores, and for estimating corresponding regression coefficients. Both shrinkage as well as empirical estimators are available.

::DEVELOPER

Strimmer Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

:: DOWNLOAD

 care

:: MORE INFORMATION

Citation:

BMC Bioinformatics. 2012 Oct 31;13:284. doi: 10.1186/1471-2105-13-284.
A novel algorithm for simultaneous SNP selection in high-dimensional genome-wide association studies.
Zuber V, Duarte Silva AP, Strimmer K.

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