SIM
:: DESCRIPTION
SIM is a software of cell- and gene-based computer model for mammalian somitogenesis, simulating a gene regulatory network combining clock (Hes1/7) and gradient (Tbx6, Fgf8, Wnt3a) with Delta/Notch signaling resulting in dynamic gene expression patterns as observed in vivo finally leading to boundary formation.
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::DEVELOPER
Institute of Experimental Genetics , German Research Center for Environmental Health (GmbH)
:: SCREENSHOTS
:: REQUIREMENTS
- Windows / Linux / MacOsX
- Java
:: DOWNLOAD
:: MORE INFORMATION
Citation
Tiedemann HB, Schneltzer E, Zeiser S, Hoesel B, Beckers J, Przemeck GKH, Hrabě de Angelis M. (2012).
From dynamic Expression patterns to Boundary Formation in the Presomitic mesoderm
PLoS Comput Biol 8(6): e1002586. doi:10.1371/journal.pcbi.1002586