APL-OSA Beta
:: DESCRIPTION
APL-OSA can identify a genetically homogenous subset of families based on a trait-related covariate. APL-OSA then tests the relationship between the association statistics (i.e., the APL statistics) calculated based on the subset and the family-specific covariate. APL-OSA is based on the OSA method for linkage (Hauser et al. 2004) and the family-based association test, APL (Martin et al. 2003; Chung et al. 2006). Thus, APL-OSA has similar properties with OSA and APL. Bi-alleleic markers such as SNPs are accepted by APL-OSA. APL-OSA is a single-marker test and considers one covariate each time.
::DEVELOPER
Duke Molecular Physiology Institute
:: SCREENSHOTS
N/A
:: REQUIREMENTS
- Windows/Linux
:: DOWNLOAD
:: MORE INFORMATION
Citation
RH Chung, S Schmidt, ER Martin, ER Hauser.
“Ordered-subset analysis (OSA) for family-based association mapping of complex traits..”
Genetic epidemiology 32.7 (November, 2008): 627-37.