PIVO is a program that reconstructs ancestral gene orders on complex phylogenies. Because it uses the DCJ model, it can handle linear, circular, and multilinear genomes. PIVO is mainly targeted at reconstructing rerrangement histories of mitochondrial genomes.
Albert Herencsár, Broňa Brejová . An Improved Algorithm for Ancestral Gene Order Reconstruction.
In V. Kurkova, L. Bajer, V. Svatek, ed., Information Technologies – Applications and Theory (ITAT), number 1003 in CEUR-WS, pp. 46-53, Jasna, Slovakia, 2014.
ATGme is an open-source web-based application which can in a first step identify rare and highly rare codons from most organisms, and secondly gives the user the possibility to optimize the sequence.