tRNA-derived fragment (tRF) is a novel class of regulatory small non-coding RNAs cleaved from mature tRNAs. Recent evidence has revealed that tRFs can be loaded onto Argonaute (AGO) family proteins to perform post-transcriptional regulations via substantial tRF-target gene interactions (TGIs).
tRFTar includes 920,690 predicted TGIs between 12,102 tRFs and 5,688 target genes and further provides two main functions, namely customized TGI search and tRF functional enrichment analysis.
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Zhou Y, Peng H, Cui Q, Zhou Y.
tRFTar: Prediction of tRF-target gene interactions via systemic re-analysis of Argonaute CLIP-seq datasets.
Methods. 2021 Mar;187:57-67. doi: 10.1016/j.ymeth.2020.10.006. Epub 2020 Oct 9. PMID: 33045361.