TransFIC is a method to transform Functional Impact scores taking into account the differences in basal tolerance to germline SNVs of genes that belong to different functional classes. This transformation allows to use the scores provided by well-known tools (e.g. SIFT, Polyphen2, MutationAssessor) to rank the functional impact of cancer somatic mutations. Mutations with greater transFIC are more likely to be cancer drivers.
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Abel Gonzalez-Perez, Jordi Deu-Pons and Lopez-Bigas N.
Improving the prediction of the functional impact of cancer mutations by baseline tolerance transformation.
Genome Medicine. 2012. 4:89 doi:10.1186/gm390.