ProteoCombiner v1.0 – Integrating Top-down, Bottom-up and Middle-down Proteomics data

ProteoCombiner v1.0

:: DESCRIPTION

ProteoCombiner capitalizes on the data arising from different experiments and proteomics search engines and presents the results in a user-friendly manner. Our tool also provides a rapid and easy visualization, manual validation and comparison of the identified proteoform sequences, including post-translational modifications (PTM) characterization.

::DEVELOPER

MSBIO – INSTITUT PASTEUR

:: SCREENSHOTS

:: REQUIREMENTS

  • Windows
  • The .NET framework

:: DOWNLOAD

ProteoCombiner

:: MORE INFORMATION

Citation

Lima DB, Dupré M, Duchateau M, Gianetto QG, Rey M, Matondo M, Chamot-Rooke J.
ProteoCombiner: integrating bottom-up with top-down proteomics data for improved proteoform assessment.
Bioinformatics. 2021 Aug 9;37(15):2206-2208. doi: 10.1093/bioinformatics/btaa958. PMID: 33165572.

TBnovo – De novo Protein Sequencing by combining Top-down and Bottom-up Mass Spectrometry

TBnovo

:: DESCRIPTION

TBNovo is a de novo protein sequencing software tool which combines both top down and bottom up tandem mass spectra.

::DEVELOPER

Xiaowen Liu ,CCMS The Center for Computational Mass Spectrometry

:: REQUIREMENTS

  • Linux/Windows
  • JRE

:: DOWNLOAD

 TBnovo

:: MORE INFORMATION

Citation

J Proteome Res. 2014 Jul 3;13(7):3241-8. doi: 10.1021/pr401300m. Epub 2014 Jun 18.
De novo protein sequencing by combining top-down and bottom-up tandem mass spectra.
Liu X1, Dekker LJ, Wu S, Vanduijn MM, Luider TM, Tolić N, Kou Q, Dvorkin M, Alexandrova S, Vyatkina K, Paša-Tolić L, Pevzner PA.