POLYVIEW-2D / POLYVIEW-3D / POLYVIEW-MM – Protein Structure Annotation using Sequence Profiles / Structures / Motions

POLYVIEW-2D / POLYVIEW-3D / POLYVIEW-MM

:: DESCRIPTION

The POLYVIEW-2D protein structure visualization server can be used to generate amino acid sequence annotations, such as secondary structure, relative solvent accessibility, evolutionary conservation, and physico-chemical property profiles. It can also be used to identify residues involved in protein-protein interactions and highlight other important sites and motifs.

POLYVIEW-3D is a web-based tool for macromolecular structure visualization and analysis. In particular, it provides a wide array of options for automated structural and functional analysis of proteins and their complexes. This tutorial aims to describe and illustrate the available rendering options and annotation capabilities of POLYVIEW-3D.

POLYVIEW-MM (Molecular Motion) enables animation of trajectories generated by Molecular Dynamics and related simulation techniques, as well as visualization of alternative conformers, e.g., obtained as a result of protein structure prediction methods or small molecule docking, using an intuitive web-based interface.

:: SCREENSHOTS

N/A

::DEVELOPER

Meller Lab

:: REQUIREMENTS

  • Web Browser

:: DOWNLOAD

  NO

:: MORE INFORMATION

Citation

POLYVIEW: a flexible visualization tool for structural and functional annotations of proteins.
Porollo AA, Adamczak R, Meller J.
Bioinformatics. 2004 Oct 12;20(15):2460-2. Epub 2004 Apr 8.

Nucleic Acids Res. 2010 Jul;38(Web Server issue):W662-6. doi: 10.1093/nar/gkq445. Epub 2010 May 26.
POLYVIEW-MM: web-based platform for animation and analysis of molecular simulations.
Porollo A, Meller J.

PRIAM 201303 – Sequence Profiles Generated from the ENZYME database

PRIAM 201303

:: DESCRIPTION

PRIAM (PRofils pour l’Identification Automatique du Métabolisme) is a method for automated enzyme detection in a fully sequenced genome, based on all sequences available in the ENZYME database.PRIAM relies on sets of position-specific score matrices (PSSMs) automatically tailored for each ENZYME entry. The whole Swiss-Prot database has been used to parameterise and to assess the method. As an example, PRIAM was applied to predict metabolic pathways from the complete genome of the nitrogen fixing bacterium Sinorhizobium meliloti and on the plant pathogen Ralstonia solanacearum. The results of this automated annotation method were compared with the original genome annotation and visualised on KEGG graphs in order to facilitate the interpretation of predicted metabolic pathways and to highlight potentially missing enzymes.

::DEVELOPER

PRIAM Team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux / MacOsX/ Windows
  • Java

:: DOWNLOAD

 PRIAM 

:: MORE INFORMATION

Citation

Clotilde Claudel-Renard, Claude Chevalet, Thomas Faraut and Daniel Kahn
Enzyme-specific profiles for genome annotation: PRIAM
Nucleic Acids Research, 2003, Vol. 31, No. 22 6633-6639

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