Profppikernel 1.0.4 – Protein-protein Interaction Prediction

Profppikernel 1.0.4

:: DESCRIPTION

Profppikernel uses an accelerated version of the original profile kernel to train SVM based protein-protein interaction (PPI) prediction models and to predict new PPIs from sequence alone.

::DEVELOPER

Rost Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 Profppikernel

:: MORE INFORMATION

Citation

Evolutionary profiles improve protein-protein interaction prediction from sequence.
Hamp T, Rost B.
Bioinformatics. 2015 Feb 4. pii: btv077.

DynaFace – Discrimination between Obligatory and Non-obligatory Protein-Protein Interactions

DynaFace

:: DESCRIPTION

DynaFace predicts obligatory and non-obligatory interactions among a set of 300 putative protein complexes.

::DEVELOPER

Polymer Research Center

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web browser
:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation:

DynaFace: Discrimination between Obligatory and Non-obligatory Protein-Protein Interactions Based on the Complex’s Dynamics.
Soner S, Ozbek P, Garzon JI, Ben-Tal N, Haliloglu T.
PLoS Comput Biol. 2015 Oct 27;11(10):e1004461. doi: 10.1371/journal.pcbi.1004461.

DeNovo – Virus-Host Sequence-Based Protein-Protein Interaction Prediction

DeNovo

:: DESCRIPTION

DeNovo is a sequence-based negative sampling and machine learning framework that learns from PPIs of different viruses to predict for a novel one, exploiting the shared host proteins.

::DEVELOPER

DeNovo team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux / Windows
  • MatLab

:: DOWNLOAD

 DeNovo

:: MORE INFORMATION

Citation

DeNovo: Virus-Host Sequence-Based Protein-Protein Interaction Prediction.
Eid FE, ElHefnawi M, Heath LS.
Bioinformatics. 2015 Dec 16. pii: btv737.

PPI-PS – Protein-protein Interaction based on Pairwise Similarity

PPI-PS

:: DESCRIPTION

The PPI-PS method consists of a representation of each protein sequence by a vector of pairwise similarities against large subsequences of amino acids created by a shifting window which passes over concatenated protein training sequences.

::DEVELOPER

Nazar Zaki , Bioinformatics Laboratory, UAE University.

:: SCREENSHOTS

N/A

::REQUIREMENTS

:: DOWNLOAD

 PPI-PS

:: MORE INFORMATION

Citation

BMC Bioinformatics. 2009 May 17;10:150. doi: 10.1186/1471-2105-10-150.
Protein-protein interaction based on pairwise similarity.
Zaki N, Lazarova-Molnar S, El-Hajj W, Campbell P.

Strike – Protein-protein Interaction Classification tool

Strike

:: DESCRIPTION

Strike (String Kernel) is a program which classifies protein-protein interaction into “interacting” and “non-interacting” sets based solely on amino acid sequence information. The classification is made by applying the string kernel technique. Two proteins are classified “interacting” if they contain similar subsequences of amino acids.

::DEVELOPER

Nazar Zaki , Bioinformatics Laboratory, UAE University.

:: SCREENSHOTS

N/A

::REQUIREMENTS

:: DOWNLOAD

  Strike

:: MORE INFORMATION

Citation

Adv Exp Med Biol. 2011;696:263-70. doi: 10.1007/978-1-4419-7046-6_26.
Strike: a protein-protein interaction classification approach.
Zaki N, El-Hajj W, Kamel HM, Sibai F.

ITI 2.0 – Analysis of Gene Expression data by Superimposition of a large scale Protein-protein Interaction data

ITI 2.0

:: DESCRIPTION

ITI project [Interactome-Transcriptome Integration] is a network-based robust classification of transcription profiles in cancer by large scale data integration of protein-protein interaction with DNA microarray data.

::DEVELOPER

The CRCM’s Integrative Bioinformatics

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux / Windows
  • Perl

:: DOWNLOAD

  ITI

:: MORE INFORMATION

Citation

Bioinformatics. 2012 Mar 1;28(5):672-8. doi: 10.1093/bioinformatics/bts025.
Interactome-transcriptome integration for predicting distant metastasis in breast cancer.
Garcia M, Millat-Carus R, Bertucci F, Finetti P, Birnbaum D, Bidaut G.

PrePPI – Predicting Protein-Protein Interactions by Combining Structural and non-Structural Information

PrePPI

:: DESCRIPTION

PrePPI is a database of predicted and experimentally determined protein-protein interactions (PPI) for yeast and human. Predicted interactions in the database are determined using a Bayesian framework that combines structural, functional, evolutionary and expression information.

::DEVELOPER

Barry Honig’s group 

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web Browser

:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation

PrePPI: a structure-informed database of protein-protein interactions.
Zhang QC, Petrey D, Garzón JI, Deng L, Honig B.
Nucleic Acids Res. 2013 Jan;41(Database issue):D828-33. doi: 10.1093/nar/gks1231.

PIPs 1.1 – Human Protein-Protein Interaction Predictions

PIPs 1.1

:: DESCRIPTION

PIPs is a database of predicted human protein-protein interactions. The predictions have been made using a na?ve Bayesian classifier to calculate a Score of interaction.

::DEVELOPER

The Barton Group

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web Browser

 NO

:: MORE INFORMATION

Citation

PIPs: human protein–protein interaction prediction database
Mark D. McDowall, Michelle S. Scott and Geoffrey J. Barton
Nucl. Acids Res. (2009) 37 (suppl 1): D651-D656. doi: 10.1093/nar/gkn870

LR_PPI – large-scale Prediction of Human protein-protein interaction

LR_PPI

:: DESCRIPTION

LR_PPI is a web server for large-scale prediction of human protein-protein interaction from amino acid sequence based on latent topic feature

::DEVELOPER

Computational Systems Biology Group, Shanghai Jiao Tong University

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web Browser

:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation:

J Proteome Res. 2010 Oct 1;9(10):4992-5001. doi: 10.1021/pr100618t.
Large-scale prediction of human protein-protein interactions from amino acid sequence based on latent topic features.
Pan XY1, Zhang YN, Shen HB.