noRNAlize 1.0

:: DESCRIPTION

noRNAlize is a data analysis package to analyze and normalize SHAPE (Selective 2′-Hydroxyl Acylation and Primer Extension) data. Traditionally, SHAPE requires the addition of a 3′ hairpin to the RNA for normalization. noRNAlize elminates the need for this experimental step by performing a global analysis of the SHAPE data, and establishing mean protection values. This is particularly important when SHAPE analysis is used to map crystal contacts in crystal structures as illustrated here.

::DEVELOPER

noRNAlize Team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

• Windows / MacOsX /  Linux
• MATLAB

:: DOWNLOAD

 noRNAlize

:: MORE INFORMATION

Citation:

Vicens Q, Gooding AR, Laederach A, Cech TR,
Local RNA structural changes induced by crystallization are revealed by SHAPE,
RNA, (2007)