MixMir – Mixed linear models for microRNA Motif Finding

MixMir

:: DESCRIPTION

MixMir is a program for finding microRNA motifs using gene expression and 3′ UTR sequence data.

::DEVELOPER

Kevin Chen’s group

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • Python

:: DOWNLOAD

 MixMir

:: MORE INFORMATION

Citation:

Nucleic Acids Res. 2014;42(17):e135. doi: 10.1093/nar/gku672. Epub 2014 Jul 31.
MixMir: microRNA motif discovery from gene expression data using mixed linear models.
Diao L, Marcais A, Norton S, Chen KC

MotifIndexer – de novo Promoter Motifs Finding program

MotifIndexer

:: DESCRIPTION

MotifIndexer is a comprehensive strategy for de novo identification of DNA regulatory motifs at a genome level.

::DEVELOPER

Dinesh-Kumar Laboratory

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 MotifIndexer

:: MORE INFORMATION

Citation

Ma S, Bachan S, Porto M, Bohnert HJ, Snyder M and Dinesh-Kumar SP. (2012)
Discovery of stress responsive DNA regulatory motifs in Arabidopsis.
PLoS ONE 7:e43198

CompareProspector – Sequence Motif Finding Algorithm

CompareProspector

:: DESCRIPTION

CompareProspector is a sequence motif-finding algorithm which extends Gibbs sampling by biasing the search in promoter regions conserved across species. Using human–mouse comparison, CompareProspector correctly identified the known motifs for transcription factors Mef2, Myf, Srf, and Sp1 from a set of human muscle-specific genes. It also discovered the NFAT motif from genes upregulated by CD28 stimulation in T cells, which suggests the direct involvement of NFAT in mediating CD28 stimulatory signal. Using C. elegans–C. briggsae comparison, CompareProspector found the PHA-4 motif from pharyngeally expressed genes and the UNC-86 motif from genes known to be regulated by UNC-86. CompareProspector outperformed many other computational motif-finding programs tested, demonstrating the power of comparative genomics-based biased sampling in eukaryotic regulatory element identification.

::DEVELOPER

X. Shirley Liu Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows with Cygwin / Linux / Mac OsX
  • C Complier

:: DOWNLOAD

 CompareProspector

:: MORE INFORMATION

Citation:

Liu Y, Liu XS, Wei L, Altman RB, Batzoglou S.
Eukaryotic regulatory element conservation analysis and identification using comparative genomics.
Genome Res. 2004 Mar;14(3):451-8.

MotifCut 0.1 beta – Non-parametric graph-based Motif Finding algorithm

MotifCut 0.1 beta

:: DESCRIPTION

MotifCut is a DNA motif-finding algorithm using a Maximum Density Subgraph.

::DEVELOPER

Serafim Batzoglou

:: SCREENSHOTS

MotifCut

:: REQUIREMENTS

  • Linux/Windows/MacOsX
  • C++ Compiler

:: DOWNLOAD

  MotifCut

:: MORE INFORMATION

Citation

Bioinformatics. 2006 Jul 15;22(14):e150-7.
MotifCut: regulatory motifs finding with maximum density subgraphs.
Fratkin E, Naughton BT, Brutlag DL, Batzoglou S.

ALSE 1.07 – Motif Finding Tool

ALSE 1.07

:: DESCRIPTION

ALSE (ALl SEquences) compares favorably against common motif-finding programs such as SeedSearch and MEME in all cases and performs very well, especially when each input sequence contains more than one binding site.

::DEVELOPER

Bioinformatics Research Group of Hong Kong University

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

  ALSE

:: MORE INFORMATION

Citation:

Bioinformatics. 2006 Sep 15;22(18):2217-23. Epub 2006 Jul 26.
Finding motifs from all sequences with and without binding sites.
Leung HC, Chin FY.

 

AlignACE 3.0 – Motif Finding

AlignACE 3.0

:: DESCRIPTION

AlignACE (Aligns Nucleic Acid Conserved Elements) is a program which finds sequence elements conserved in a set of DNA sequences.

::DEVELOPER

George M. Church Laboratory

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows/Linux
  • Perl

:: DOWNLOAD

 AlignACE

:: MORE INFORMATION

Citation

Hughes, JD, Estep, PW, Tavazoie S, & GM Church,
Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae,
Journal of Molecular Biology 2000 Mar 10;296(5):1205-14.