HotMAPS v1.1.4 – Hotspot Missense mutation Areas in Protein Structures

HotMAPS v1.1.4

:: DESCRIPTION

HotMAPS detects somatic mutation hotspot regions in 3D protein structures.

::DEVELOPER

Karchin Lab

:: SCREENSHOTS

N/A

::REQUIREMENTS

Linux
Python

:: DOWNLOAD

HotMAPS

:: MORE INFORMATION

Citation

Tokheim C, Bhattacharya R, Niknafs N, Gygax DM, Kim R, Ryan M, Masica DL, Karchin R.
Exome-Scale Discovery of Hotspot Mutation Regions in Human Cancer Using 3D Protein Structure.
Cancer Res. 2016 Jul 1;76(13):3719-31. doi: 10.1158/0008-5472.CAN-15-3190. Epub 2016 Apr 28. PMID: 27197156; PMCID: PMC4930736.

SAAFEC-SEQ – Pedict the stability Changes upon a Single Mutation in Protein

SAAFEC-SEQ

:: DESCRIPTION

SAAFEC-SEQ is an online application for calculating folding free energy changes in proteins caused by missense mutations for provided protein sequence.

::DEVELOPER

Professor Emil Alexov Group

:: SCREENSHOTS

N/A

:: REQUIREMENTS

Web browser

:: DOWNLOAD

SAAFEC-SEQ

:: MORE INFORMATION

Citation

Li G, Panday SK, Alexov E.
SAAFEC-SEQ: A Sequence-Based Method for Predicting the Effect of Single Point Mutations on Protein Thermodynamic Stability.
Int J Mol Sci. 2021 Jan 9;22(2):606. doi: 10.3390/ijms22020606. PMID: 33435356; PMCID: PMC7827184.

SAAFEC: Predicting the Effect of Single Point Mutations on Protein Folding Free Energy Using a Knowledge-Modified MM/PBSA Approach.
Getov I, Petukh M, Alexov E.
Int J Mol Sci. 2016 Apr 7;17(4). pii: E512. doi: 10.3390/ijms17040512.