myPhyloDB is an open-source software package aimed at developing a user-friendly web-interface for accessing and analyzing all of your laboratory’s microbial ecology data.
SUPER-FOCUS (SUbsystems Profile by databasE Reduction using FOCUS) an agile homology-based approach using a reduced SEED database to report the subsystems present in metagenomic samples and profile their abundances.
Amordad is a database engine for comparing metagenomic data at massive scale. It first obtains the sequence signature of metagenomes and organizes them as points in high dimensional space.
MicrobeGPS is a bioinformatics tool for the analysis of metagenomic sequencing data. The goal is to profile the composition of metagenomic communities as accurately as possible and present the results to the user in a convenient manner.
growthpred predicts the minimum generation time for a bacterial or archaeal organism based on its codon usage bias intensity (CUB). The CUB index is calculated given two input sets of sequences: 1) highly expressed genes 2) other genes. The application runs 1000 bootstraps and outputs the average and the standard deviation of the predictions.
Metastats, employs the false discovery rate to improve specificity in high-complexity environments, and separately handles sparsely-sampled features using Fisher’s exact test. Under a variety of simulations, we show that Metastats performs well compared to previously used methods, and significantly outperforms other methods for features with sparse counts. We demonstrate the utility of our method on several datasets including a 16S rRNA survey of obese and lean human gut microbiomes, COG functional profiles of infant and mature gut microbiomes, and bacterial and viral metabolic subsystem data inferred from random sequencing of 85 metagenomes. The application of our method to the obesity dataset reveals differences between obese and lean subjects not reported in the original study. For the COG and subsystem datasets, we provide the first statistically rigorous assessment of the differences between these populations.