pclogit 0.1 / gfusetlpclogit 1.0 – Penalized Conditional/Unconditional Logistic Regression

pclogit 0.1 / gfusetlpclogit 1.0

:: DESCRIPTION

pclogit (penalized conditional logistic) is an R package for penalized conditional/unconditional logistic regression using a network-based peanlty for matched/unmatched case-control data with grouped or graph-constrained variables. The algorithm is efficient for fitting the regularization path and for providing selection probabilities of each predictor for the anaylsis of high-dimensional matched/unmatched case-control data. It uses cyclical coordinate descent in a pathwise fashion.

gfusetlpclogit is an R package for penalized conditional/unconditional logistic regression that combines the truncated lasso penalty and a graph fuse-lasso penalty to induce parsimonious and consistent models, also to incorporate the network structure of correlated CpG sites in a gene without introducing extra bias. The algorithm is efficient for fitting the regularization path and for providing selection probabilities of each predictor for the anaylsis of high-dimensional matched/unmatched case-control data.

::DEVELOPER

Wang Lab @ Biostatistics Department

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • R

:: DOWNLOAD

 pclogit , gfusetlpclogit

:: MORE INFORMATION

Citation

Sun H, Wang S (2013)
Network-based regularization for matched case-control analysis of high-dimensional DNA methylation data
Statistics in Medicine, 32:2127–2139

Sun H, Wang S (2012)
Penalized Logistic Regression for High-dimensional DNA Methylation Data with Case-Control Studies
Bioinformatics, 28:1368-1375

LRMotifs 1.0 – Logistic Regression-Based DNA Motif Discovery

LRMotifs 1.0

:: DESCRIPTION

LRMotifs is a novel method of DNA sequence motif discovery based on logistic regression and rigorous hypothesis testing.

::DEVELOPER

David M Simcha dsimcha@gmail.com

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 LRMotifs

:: MORE INFORMATION

Citation

PLoS One. 2012;7(11):e47836. doi: 10.1371/journal.pone.0047836. Epub 2012 Nov 7.
The limits of de novo DNA motif discovery.
Simcha D1, Price ND, Geman D.

LoQuM 0.2 – LOgistic Regression tool for Calibrating the QUality of Short Read Mappings

LoQuM 0.2

:: DESCRIPTION

LoQuM assigns reliable mapping quality scores to mappings of Illumina reads returned by an alignment tool.

::DEVELOPER

LoQuM team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows/Linux/MacOsX
  • Python
  • R

:: DOWNLOAD

 LoQuM

:: MORE INFORMATION

Citation

Accurate estimation of short read mapping quality for next-generation genome sequencing.
Ruffalo M, Koyutürk M, Ray S, LaFramboise T.
Bioinformatics. 2012 Sep 15;28(18):i349-i355. doi: 10.1093/bioinformatics/bts408.

LRpath – Pathway Analysis using Logistic Regression

LRpath / RNA-Enrich

:: DESCRIPTION

LRpath performs gene set enrichment testing using logistic regression, and allows the data to remain on a continuous scale. This web-based tool tests against several annotation databases, including Gene Ontology, multiple pathway databases, metabolite, transcription factor and microRNA target sets, and literature-derived annotations. LRpath also includes clustering analysis functionality, allowing you to identify and compare biological concept signatures across multiple studies. LRpath performs well with both small and large sample sizes. Additional benefits of using the LRpath program include (1) the ability to perform both “directional” and “non-directional” enrichment tests that allow for two different perspectives and (2) the ability to easily compare and visualize results across multiple studies using LRpath clustering.

RNA-Enrich is faster than LRpath and best for RNA-seq data that exhibit a relationship between gene read counts and significance of differential gene expression (e.g. genes with higher read counts may have more significant p-values, and vice versa).

::DEVELOPER

The Sartor Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web Browser

:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation

RNA-Enrich: A cut-off free functional enrichment testing method for RNA-seq with improved detection power.
Lee C, Patil S, Sartor MA.
Bioinformatics. 2015 Nov 25. pii: btv694.

BMC Genomics. 2012 Oct 4;13:526. doi: 10.1186/1471-2164-13-526.
LRpath analysis reveals common pathways dysregulated via DNA methylation across cancer types.
Kim JH1, Karnovsky A, Mahavisno V, Weymouth T, Pande M, Dolinoy DC, Rozek LS, Sartor MA.

SMLR 1.1.0 – Sparse Multinomial Logistic Regression

SMLR 1.1.0

:: DESCRIPTION

SMLR is an efficient implementation of a true multiclass probabilistic classifier based on the well-studied multinomial logistic regression framework.

::DEVELOPER

Alex Hartemink

:: SCREENSHOTS

SMLR

:: REQUIREMENTS

  • Windows/Linux/MacOsX
  • Java

:: DOWNLOAD

 SMLR

:: MORE INFORMATION

Citation

Pac Symp Biocomput. 2006:279-90.
Finding diagnostic biomarkers in proteomic spectra.
Pratapa PN, Patz EF Jr, Hartemink AJ.