LIQA – Long-read Isoform Quantification and Analysis

LIQA

:: DESCRIPTION

LIQA (Long-read Isoform Quantification and Analysis) is an Expectation-Maximization based statistical method to quantify isoform expression and detect differential alternative splicing (DAS) events using long-read RNA-seq data. LIQA incorporates base-pair quality score and isoform-specific read length information to assign different weights across reads instead of summarizing isoform-specific read counts directly. Moreover, LIQA can detect DAS events between conditions using isoform usage estimates.

::DEVELOPER

Wang Genomics Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • Pyton

:: DOWNLOAD

LIQA

:: MORE INFORMATION

Citation

Yu Hu, Li Fang, Xuelian Chen, Jiang F. Zhong, Mingyao Li, Kai Wang.
LIQA: Long-read Isoform Quantification and Analysis.
2020. bioRxiv doi: https://doi.org/10.1101/2020.09.09.289793