HLP – Predicting Half-life of Peptides in Intestine like Environment

HLP

:: DESCRIPTION

HLP is a server developed for predicting half-life of peptides in intestine like environment. It generates all possible mutants (single mutation at each position per cycle) for a peptide and predict/calculate half-life and physicochemical properties (e.g. charge, polarity, hydrophobicity, volume, pK) of mutant peptides.

::DEVELOPER

HLP team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

Web Browser

:: DOWNLOAD

:: MORE INFORMATION

Citation

Designing of peptides with desired half-life in intestine-like environment.
Sharma A, Singla D, Rashid M, Raghava GP.
BMC Bioinformatics. 2014 Aug 20;15:282. doi: 10.1186/1471-2105-15-282.

PEPlife – Database of Half-life of Peptides

PEPlife

:: DESCRIPTION

PEPlife is a manually curated database of experimentally validated therapeutic peptides and their halflives. In this database, peptides have been collected from both published articles as well as from patents.Each entry provides comprehensive information about a peptide that includes its sequence, chemical modifications incorporated, biological activity possessed, its half-life, the assay used to determine its half-life etc.

::DEVELOPER

PEPlife team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

Web Browser

:: DOWNLOAD

:: MORE INFORMATION

Citation

PEPlife: A Repository of the Half-life of Peptides.
Mathur D, Prakash S, Anand P, Kaur H, Agrawal P, Mehta A, Kumar R, Singh S, Raghava GP.
Sci Rep. 2016 Nov 7;6:36617. doi: 10.1038/srep36617.

PlifePred – Design Half-life of Peptides in Blood

PlifePred

:: DESCRIPTION

PlifePred is prediction server for predicting the half-life of peptides in blood. Users can use PlifePred to increase or decrease the half-life of their peptide by generating mutants. The server facilitates designing the half-life of a peptide by generating its mutants and predicting their half-life and physiochemical properties.The user can screen and select the peptide with suitable properties desired.

::DEVELOPER

PlifePred team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

Web Browser

:: DOWNLOAD

:: MORE INFORMATION

Citation

In silico approaches for predicting the half-life of natural and modified peptides in blood.
Mathur D, Singh S, Mehta A, Agrawal P, Raghava GPS.
PLoS One. 2018 Jun 1;13(6):e0196829. doi: 10.1371/journal.pone.0196829.

HALO 1.3 – Precise RNA de novo Transcript Half-life Determination

HALO 1.3

:: DESCRIPTION

HALO (Half-life Organizer) is the first software for the precise determination of transcript half-lives from measurements of RNA de novo transcription. In addition, methods for quality control, filtering and normalization are supplied. HALO provides a graphical user interface, command line tools and a well-documented Java API. Thus, it can be used both by biologists to determine transcript half-lives fast and reliably with the user interfaces provided as well as software developers integrating transcript half-life analysis into other gene expression profiling pipelines.

::DEVELOPER

Institut für Informatik, Ludwig-Maximilians-Universität München

:: SCREENSHOTS

:: REQUIREMENTS

Windows / Linux / Mac OsX
Java

:: DOWNLOAD

HALO

:: MORE INFORMATION

Citation

Caroline C. Friedel, Stefanie Kaufmann, Lars Dölken, Ralf Zimmer.
HALO – A Java framework for precise transcript half-life determination.
Bioinformatics, vol 26, no. 9, pp. 1264-1266, May 2010.