Tag: First

RUNTC – Estimator of First Coalescent Time

RUNTC

:: DESCRIPTION

RUNTC is an estimator of first coalescent time, which is the time when a copy of a gene most recently shared ancestry with other copies of that gene. This is also an estimate of the upper bound of when a mutation has arisen, and it can be used to study the ages of alleles that are found in a population.

::DEVELOPER

the Hey lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • Python

:: DOWNLOAD

RUNTC

:: MORE INFORMATION

Citation:

Platt A, Pivirotto A, Knoblauch J, Hey J.
An estimator of first coalescent time reveals selection on young variants and large heterogeneity in rare allele ages among human populations.
PLoS Genet. 2019 Aug 19;15(8):e1008340. doi: 10.1371/journal.pgen.1008340. PMID: 31425500; PMCID: PMC6715256.

FirstEF – Human First Exon Finder

FirstEF

:: DESCRIPTION

FirstEF (First Exon Finder) is a 5′ terminal exon and promoter prediction program. It consists of different discriminant functions structured as a decision tree. The probabilistic models are optimized to find potential first donor sites and CpG-related and non-CpG-related promoter regions based on discriminant analysis. For every potential first donor site (GT) and an upstream promoter region, FirstEF decides whether or not the intermediate region can be a potential first exon, based on a set of quadratic discriminant functions.

::DEVELOPER

Michael Zhang Computational Biology Laboratory

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web Browser

:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation

Computational identification of promoters and first exons in the human genome.
Davuluri RV, Grosse I, Zhang MQ.
Nat Genet. 2001 Dec;29(4):412-7. Erratum in: Nat Genet 2002 Nov;32(3):459.