DeepGS 1.2 – Predicting Phenotypes from Genotypes using Deep Learning

DeepGS 1.2

:: DESCRIPTION

DeepGS is a R package for predicting phenotypes from genotypes using deep learning techniques.

::DEVELOPER

Ma Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux / Windows
  • R

:: DOWNLOAD

DeepGS

:: MORE INFORMATION

Citation

Ma W, Qiu Z, Song J, Li J, Cheng Q, Zhai J, Ma C.
A deep convolutional neural network approach for predicting phenotypes from genotypes.
Planta. 2018 Nov;248(5):1307-1318. doi: 10.1007/s00425-018-2976-9. Epub 2018 Aug 12. PMID: 30101399.

DeepRescore – Rescore PSMs leveraging Deep Learning-derived Peptide Features

DeepRescore

:: DESCRIPTION

DeepRescore is an immunopeptidomics data analysis tool that leverages deep learning-derived peptide features to rescore peptide-spectrum matches (PSMs).

::DEVELOPER

the Zhang Lab

:: SCREENSHOTS

n/a

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

DeepRescore

:: MORE INFORMATION

Citation

Li K, Jain A, Malovannaya A, Wen B, Zhang B.
DeepRescore: Leveraging Deep Learning to Improve Peptide Identification in Immunopeptidomics.
Proteomics. 2020 Nov;20(21-22):e1900334. doi: 10.1002/pmic.201900334. Epub 2020 Sep 27. PMID: 32864883; PMCID: PMC7718998.

AutoRT v1.0 – Peptide Retention Time Prediction using Deep Learning

AutoRT v1.0

:: DESCRIPTION

AutoRT is a peptide sequence-based RT prediction tool developed using automated deep learning and transfer learning. It can provide high accurate RT prediction with models trained using a small number of peptides (~1000) with transfer learning.

::DEVELOPER

the Zhang Lab

:: SCREENSHOTS

n/a

:: REQUIREMENTS

  • Linux
  • Python

:: DOWNLOAD

AutoRT

:: MORE INFORMATION

Citation

Wen B, Li K, Zhang Y, Zhang B.
Cancer neoantigen prioritization through sensitive and reliable proteogenomics analysis.
Nat Commun. 2020 Apr 9;11(1):1759. doi: 10.1038/s41467-020-15456-w. PMID: 32273506; PMCID: PMC7145864.

DeepFun – Tissue and Cell Type specific Deep Learning Sequence-based model to Decipher Noncoding Variant Effects.

DeepFun

:: DESCRIPTION

DeepFun is a deep-learning-based model for functional evaluation of genetic variants at the single-base resolution.

::DEVELOPER

Bioinformatics and Systems Medicine Laboratory

:: SCREENSHOTS

n/a

:: REQUIREMENTS

  • Web browser

:: DOWNLOAD

NO

:: MORE INFORMATION

Citation:

Pei G, Hu R, Jia P, Zhao Z.
DeepFun: a deep learning sequence-based model to decipher non-coding variant effect in a tissue- and cell type-specific manner.
Nucleic Acids Res. 2021 Jul 2;49(W1):W131-W139. doi: 10.1093/nar/gkab429. PMID: 34048560; PMCID: PMC8262726.

DeepARG 1.0.2 – Deep Learning Approach for Predicting Antibiotic Resistance Genes in Metagenomes

DeepARG 1.0.2

:: DESCRIPTION

DeepARG is a machine learning solution that uses deep learning to characterize and annotate antibiotic resistance genes in metagenomes. It is composed of two models for two types of input: short sequence reads and gene-like sequences.

::DEVELOPER

Professor Zhang Liqing’s Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • Python

:: DOWNLOAD

DeepARG

:: MORE INFORMATION

Citation

Arango-Argoty G, Garner E, Pruden A, Heath LS, Vikesland P, Zhang L.
DeepARG: a deep learning approach for predicting antibiotic resistance genes from metagenomic data.
Microbiome. 2018 Feb 1;6(1):23. doi: 10.1186/s40168-018-0401-z. PMID: 29391044; PMCID: PMC5796597.

D-GEX 1.01 – Deep Learning for Gene Expression Inference

D-GEX 1.01

:: DESCRIPTION

DGEX is a deep learning method to infer the expression of target genes from the expression of landmark genes.

::DEVELOPER

CBCL Lab (Computational Biology and Computational Learning) @ UCI

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux/ Windows/MacOsX
  • Python

:: DOWNLOAD

 D-GEX

:: MORE INFORMATION

Citation

Gene expression inference with deep learning.
Chen Y, Li Y, Narayan R, Subramanian A, Xie X.
Bioinformatics. 2016 Feb 11. pii: btw074.

DeepSEA 0.94c -Deep learning-based algorithmic framework for Predicting Chromatin Effects

DeepSEA 0.94c

:: DESCRIPTION

DeepSEA is a deep learning-based algorithmic framework for predicting the chromatin effects of sequence alterations with single nucleotide sensitivity. DeepSEA can accurately predict the epigenetic state of a sequence, including transcription factors binding, DNase I sensitivities and histone marks in multiple cell types, and further utilize this capability to predict the chromatin effects of sequence variants and prioritize regulatory variants.

::DEVELOPER

Troyanskaya Laboratory

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

DeepSEA

:: MORE INFORMATION

Citation

Zhou J, Troyanskaya OG.
Predicting effects of noncoding variants with deep learning-based sequence model.
Nat Methods. 2015 Oct;12(10):931-4. doi: 10.1038/nmeth.3547. Epub 2015 Aug 24. PMID: 26301843; PMCID: PMC4768299.

DeepMod v0.1.3 – Deep-learning tool for DNA Methylation Detection on Nanopore data

DeepMod v0.1.3

:: DESCRIPTION

DeepMod is a computational tool which takes long-read signals as input and outputs modification summary for each genomic position in a reference genome together with modification prediction for each base in a long read.

::DEVELOPER

Wang Genomics Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • Python

:: DOWNLOAD

DeepMod

:: MORE INFORMATION

Citation

Liu Q, Fang L, Yu G, Wang D, Xiao CL, Wang K.
Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data.
Nat Commun. 2019 Jun 4;10(1):2449. doi: 10.1038/s41467-019-10168-2. PMID: 31164644; PMCID: PMC6547721.

Dove – A Deep-learning based dOcking decoy eValuation mEthod

Dove

:: DESCRIPTION

Dove is a deep learning based protein docking model evluation method.It will use the atom information such as postions, types, energy scores in the interface area to judge if the docking model is reasonable.

::DEVELOPER

Kihara Bioinformatics Laboratory

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • Python

:: DOWNLOAD

Dove

:: MORE INFORMATION

Citation

Bioinformatics. 2019 Nov 20. pii: btz870. doi: 10.1093/bioinformatics/btz870. [Epub ahead of print]
Protein Docking Model Evaluation by 3D Deep Convolutional Neural Networks.
Wang X, Terashi G, Christoffer CW, Zhu M, Kihara D.

DeepSynergy – Predicting Anti-cancer Drug Synergy with Deep Learning

DeepSynergy

:: DESCRIPTION

DeepSynergy is a Deep Learning model for the prediction of synergy scores. It was trained on more than 22,000 samples based on 39 different cancer cell lines and combinations of 38 different drugs. DeepSynegy significantly outperformed other state-of-the-art machine learning methods.

::DEVELOPER

Institute of Bioinformatics, Johannes Kepler University Linz

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web browser

:: DOWNLOAD

DeepSynergy

:: MORE INFORMATION

Citation

DeepSynergy: predicting anti-cancer drug synergy with Deep Learning.
Preuer K, Lewis RPI, Hochreiter S, Bender A, Bulusu KC, Klambauer G.
Bioinformatics. 2018 May 1;34(9):1538-1546. doi: 10.1093/bioinformatics/btx806.

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