MET-IDEA is compatible with a diversity of chromatographically coupled mass spectrometry systems, generates an output similar to traditional quantification methods, utilizes the sensitivity and selectivity associated with selected ion quantification, and greatly reduces the time and effort necessary to obtain large-scale organized datasets by several orders of magnitude. The functionality of MET-IDEA is illustrated using metabolomics data obtained for elicited cell culture exudates from the model legume, Medicago truncatula. The results indicate that MET-IDEA is capable of rapidly extracting semi-quantitative data from raw data files, which allows for more rapid biological insight.
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Broeckling CD, Reddy IR, Duran AL,Zhao X and Sumner LW.
MET-IDEA: data extraction tool for mass spectrometry-based metabolomics.
Anal Chem. 2006 Jul 1;78(13):4334-41.