LocNES – Locating Classical NESs in CRM1 Cargo Proteins

LocNES

:: DESCRIPTION

LocNES (Locating Nuclear Export Signals or NESs) is a Support Vector Machine (SVM) predictor that locates classical nuclear export signals (NESs) in CRM1 cargoes. Export-Karyopherinβ CRM1 recognizes hundreds of broadly functioning proteins. Most CRM1 cargoes contain the classical NES (also known as leucine-rich NESs), a peptide with 8-15 amino acids, regularly spaced with conserved hydrophobic residues.

::DEVELOPER

Chook Lab,UT Southwestern Medical Center

:: SCREENSHOTS

N/A

:: REQUIREMENTS

Web Browser

:: DOWNLOAD

:: MORE INFORMATION

Citation

LocNES: A computational tool for locating classical NESs in CRM1 cargo proteins.
Xu D, Marquis K, Pei J, Fu SC, Cağatay T, Grishin NV, Chook YM.
Bioinformatics. 2014 Dec 15. pii: btu826.

NESmapper 1.1 – Prediction of CRM1-dependent Nuclear Export Signals

NESmapper 1.1

:: DESCRIPTION

NESmapper is a computational tool to predict nuclear export signals (NESs) by using profiles that had been further optimized by training and combining the amino acid properties of the NES-flanking regions.

::DEVELOPER

NESmapper team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

Linux

:: DOWNLOAD

NESmapper

:: MORE INFORMATION

Citation

NESmapper: accurate prediction of leucine-rich nuclear export signals using activity-based profiles.
Kosugi S, Yanagawa H, Terauchi R, Tabata S.
PLoS Comput Biol. 2014 Sep 18;10(9):e1003841. doi: 10.1371/journal.pcbi.1003841.