SPREG 2.0 – Regression Analysis of Secondary Phenotype Data in Case-Control Association Studies

SPREG 2.0

:: DESCRIPTION

SPREG is a computer program for performing regression analysis of secondary phenotype data in case-control association studies. Secondary phenotypes are quantitative or qualitative traits other than the case-control status. Because the case-control sample is not a random sample of the general population, standard statistical analysis of secondary phenotype data can yield very misleading results.

::DEVELOPER

Danyu Lin

:: SCREENSHOTS

N/A

::REQUIREMENTS

  • Linux

:: DOWNLOAD

 SPREG

:: MORE INFORMATION

Citation

Lin DY, Zeng D. 2009,
Proper analysis of secondary phenotype data in case-control association studies,
Genetic Epidemiology, 33:256-265.

WISARD 1.3.2 – Workbench for Integrated Superfast Association study with Related Data

WISARD 1.3.2

:: DESCRIPTION

WISARD is a free and comprehensive Statistical Analysis toolkit for omics data.

::DEVELOPER

WISARD team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows / Linux / Mac OsX

:: DOWNLOAD

 WISARD

:: MORE INFORMATION

Citation

Lee S, Choi S, Yoon J, Park T and Won S,
“A workbench for family-based genetic analysis using next-generation DNA sequencing data”,
submitted.

mRNA by SNP Browser 1.0.1 – Graphical Overviews of Whole-genome Association Study

mRNA by SNP Browser 1.0.1

:: DESCRIPTION

mRNA by SNP Browser” is an interactive package that provides graphical overviews of whole-genome association studies of datasets with very rich phenotypic information, such as global surveys of gene expression. The software incorporates a generic eQTL database and provides a graphic interface for browsing association between 54,675 transcript levels and 406,912 SNPs. For each transcript, our browser can tabulate and plot association test statistics (p-value<0.001), estimates of effect size and allele information across the genome. The browser automatically links results to the UCSC genome browser where users can examine each transcript in its genomic context. In addition to browsing the results by transcript or by position, results can be searched for information on specific SNPs. LD and tag information is provided for SNPs not in our database but evaluated by the International Hapmap Consortium.

::DEVELOPER

Liming Liang

:: SCREENSHOTS

:: REQUIREMENTS

  • Windows

:: DOWNLOAD

 mRNA by SNP Browser

:: MORE INFORMATION

Citation

Dixon AL*, Liang L*, Moffatt MF*, Chen W, Heath S, Wong KCC, Taylor J, Gut I, Farrall M, Lathrop GM, Abecasis GR, Cookson WOC (2007).
A genome-wide association study of global gene expression.
Nat Genet 39, 1202-1207 | doi:10.1038/ng2109

CaTS 0.0.2 – Power Calculator for Two Stage Association Studies

CaTS 0.0.2

:: DESCRIPTION

CaTS is a simple, multi-platform interface for carrying out power calculations for large genetic association studies, including two stage genome wide association studies.

::DEVELOPER

Abecasis Lab

:: SCREENSHOTS

:: REQUIREMENTS

  • Windows / Mac /  Linux

:: DOWNLOAD

CaTS

:: MORE INFORMATION

Citation:

Skol AD, Scott LJ, Abecasis GR and Boehnke M
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies.
Nat Genet (2006) 38:209-13

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gs 2.0 – Generating Samples for Association Studies based on HapMap data

gs 2.0

:: DESCRIPTION

gs can be used to generate samples in testing algorithms for tag SNP selection, haplotype inference, as well as epistatic detection.

::DEVELOPER

Jing Li

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows / Linux /MacOsX

:: DOWNLOAD

 gs

:: MORE INFORMATION

Citation

Li, J and Y Chen.
Generating samples for association studies based on HapMap data.
BMC Bioinformatics 9:44, 2008.