EWRA – Edge-Weighted Reconstruction integrating aDNA Assembly graph

EWRA

:: DESCRIPTION

The EWRA algorithm computes a parsimonious reconstruction of marker adjacencies minimizing the Single-Cut-or-Join (SCJ) distance along a given phylogenetic tree, including the information provided by an assembly graph of ancient DNA (aDNA) data at one internal node of the tree.

::DEVELOPER

Computational Methods for Paleogenomics and Comparative Genomics

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

EWRA

:: MORE INFORMATION

Citation

Luhmann N, Chauve C, Stoye J, Wittler R.
Scaffolding of Ancient Contigs and Ancestral Reconstruction in a Phylogenetic Framework.
IEEE/ACM Trans Comput Biol Bioinform. 2018 Nov-Dec;15(6):2094-2100. doi: 10.1007/978-3-319-12418-6_17. Epub 2018 Mar 15. PMID: 29993816.

AGapEs – Gap filling based on Template Sequence for aDNA data

AGapEs

:: DESCRIPTION

AGapEs (ancestral gap estimation) is an optimization-based mathod to fill in inter-contig gaps using a combination of a template obtained from related extant genomes and aDNA reads.

::DEVELOPER

Computational Methods for Paleogenomics and Comparative Genomics

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

AGapEs

:: MORE INFORMATION

Citation

Luhmann N, Doerr D, Chauve C.
Comparative scaffolding and gap filling of ancient bacterial genomes applied to two ancient Yersinia pestis genomes.
Microb Genom. 2017 Jul 8;3(9):e000123. doi: 10.1099/mgen.0.000123. PMID: 29114402; PMCID: PMC5643016.

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