SIM

:: DESCRIPTION

SilentMutations (SIM) can analyze the effect of multiple point mutations on the secondary structures of two interacting viral RNAs. It simulates destructive and compensatory mutants of two key regions from a single-stranded RNA, which can then be utilized for the combinatorial in vitro analysis of RNA-RNA interactions.

::DEVELOPER

RNA Bioinformatics and High Throughput Analysis Jena

:: SCREENSHOTS

N/A

:: REQUIREMENTS

• Linux/ Windows
• Python
• numpy
• viennaRNA

:: DOWNLOAD

SIM

:: MORE INFORMATION

Citation

D. Desiro, M. Hölzer, B. Ibrahim, and M. Marz,
SilentMutations (SIM): a tool for analyzing long-range RNA-RNA interactions in viral genomes and structured RNAs
Virus Res. 2019 Jan 15;260:135-141. doi: 10.1016/j.virusres.2018.11.005. Epub 2018 Nov 12.