RUNTC is an estimator of first coalescent time, which is the time when a copy of a gene most recently shared ancestry with other copies of that gene. This is also an estimate of the upper bound of when a mutation has arisen, and it can be used to study the ages of alleles that are found in a population.
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Platt A, Pivirotto A, Knoblauch J, Hey J.
An estimator of first coalescent time reveals selection on young variants and large heterogeneity in rare allele ages among human populations.
PLoS Genet. 2019 Aug 19;15(8):e1008340. doi: 10.1371/journal.pgen.1008340. PMID: 31425500; PMCID: PMC6715256.