ProStar (Promoter Structural Parameters) is a software for the prediction of promoter regions based on atomic molecular dynamics simulations of small oligonucleotides has been developed. The software works independently of gene structure conservation and orthology and of the presence of detectable sequence features. Results obtained with our method confirm the existence of a hidden physical code that modulates genome expression.
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J Ramon Goni, Alberto Perez, David Torrents and Modesto Orozco.
Determining promoter location based on DNA structure first-principles calculations
Genome Biology 2007, 8:R263